小脑浦肯野细胞缺失并非特发性震颤的特征性表现。
Cerebellar Purkinje cell loss is not pathognomonic of essential tremor.
机构信息
Saskatchewan Health Region, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan S7N 0W8, Canada.
出版信息
Parkinsonism Relat Disord. 2011 Jan;17(1):16-21. doi: 10.1016/j.parkreldis.2010.08.009.
BACKGROUND
Most of the literature on pathology of essential tremor (ET) has reported no consistent abnormalities. Some recent studies however indicate that cerebellar Purkinje cell (PC) loss is the pathological basis of ET in most patients.
OBJECTIVE
To compare cerebellar PC loss in ET, with normal and tremor dominant Parkinson's disease [PD] control brains.
METHODS
Cerebellar PC counts were performed in seven ET, six PD and two normal control brains. Three different counting methods - sectioned through nucleolus, through nucleus and through any part of PC body, were used to count the PC.
RESULTS
There were individual differences in the PC counts both in the ET and the PD cases. In all three subgroups, there was a reduction in the number of PC with advancing age. When the individuals of comparable age in the three subgroups were considered, there was no clear distinction between ET, PD and normal control subjects. There was no association between the degree of PC loss and the severity or the duration of ET.
CONCLUSION
Our study militates against the hypothesis that PC loss is pathognomonic of ET.
背景
大多数关于原发性震颤（ET）的病理学文献都没有报告一致的异常。然而，一些最近的研究表明，小脑浦肯野细胞（PC）丢失是大多数患者 ET 的病理基础。
目的
比较 ET、正常和震颤为主的帕金森病[PD]对照脑的小脑 PC 丢失。
方法
对 7 例 ET、6 例 PD 和 2 例正常对照脑进行小脑 PC 计数。使用三种不同的计数方法——通过核仁、通过核和通过 PC 体的任何部分进行计数。
结果
ET 和 PD 病例的 PC 计数均存在个体差异。在所有三个亚组中，随着年龄的增长，PC 的数量减少。当考虑三个亚组中具有可比性的个体时，ET、PD 和正常对照组之间没有明显区别。PC 丢失的程度与 ET 的严重程度或持续时间之间没有关联。
结论
我们的研究反对 PC 丢失是 ET 特征性的假说。
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