Bremen Institute for Prevention Research and Social Medicine, Germany.
Cancer Epidemiol. 2011 Feb;35(1):73-7. doi: 10.1016/j.canep.2010.06.019.
To examine whether exposures or activities in farming, forestry and related occupations explain the excess incidence of germ cell cancer (GCC) observed among male employees in one of the six car-manufacturing plants that is located in a geographic area where farming is frequent.
A cohort based case-control study was conducted among workers in six car-manufacturing plants located in areas with different industrial structure. The study involved 188 cases of germ cell cancer identified through active retrieval in 38 hospitals and 1000 controls, drawn from administrative accounting files, individually matched by year of birth (± 2 years). Information regarding tasks and exposures and potential confounding variables were obtained by face-to-face or telephone interviews. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a conditional logistic regression model adjusted for cryptorchidism and other potential confounders.
In this case-control study 5.3% of cases and 6.3% of controls ever worked in agriculture or livestock farming. No increased risks were observed for working in agriculture (OR=0.8 95% CI: 0.4-1.6), livestock farming (OR=0.8 95% CI: 0.4-1.6) or for exposure to pesticides (OR=0.7 95% CI: 0.3-1.7), for exposure to fertilizers (OR=0.8 95% CI: 0.4-1.8) and disinfectants (OR=1.0 95% CI: 0.3-2.8). There were no statistically significant increases in risk associated with ever exposure to salt based wood protection agents (OR=2.3 95% CI: 0.6-9.1), working with plywood (OR=1.4 95% CI: 0.6-3.2), coated wood (OR=1.4 95% CI: 0.5-3.9) or working in forestry (OR=1.7 95% CI: 0.5-6.4). Lagging of exposures did not alter the results.
The observed excess incidence in the cohort of automotive workers can be hardly explained by previous or concurrent work in farming or forestry. Because of the small numbers of subjects ever employed in farming the statistical power in assessing associations between agricultural work and agricultural exposures was limited and does not allow final conclusions about the association of farming related exposures and GCC risk.
研究在一个位于农业频繁地区的六家汽车制造厂之一工作的男性员工中，生殖细胞癌（GCC）发病率过高是否与农业、林业及相关职业中的暴露或活动有关。
在六家汽车制造厂（位于不同工业结构的地区）工作的工人中开展了基于队列的病例对照研究。该研究涉及通过在 38 家医院主动检索发现的 188 例生殖细胞癌病例和从行政管理档案中抽取的 1000 例对照，按照出生年份（±2 年）进行个体匹配。通过面对面或电话访谈获取关于任务和暴露以及潜在混杂变量的信息。使用条件逻辑回归模型调整隐睾症和其他潜在混杂因素后，估计比值比（OR）和 95%置信区间（CI）。
在这项病例对照研究中，5.3%的病例和 6.3%的对照曾从事农业或畜牧业工作。从事农业（OR=0.8，95%CI：0.4-1.6）、畜牧业（OR=0.8，95%CI：0.4-1.6）或接触农药（OR=0.7，95%CI：0.3-1.7）、接触肥料（OR=0.8，95%CI：0.4-1.8）和消毒剂（OR=1.0，95%CI：0.3-2.8）并未观察到风险增加。从事基于盐的木材保护剂（OR=2.3，95%CI：0.6-9.1）、胶合板（OR=1.4，95%CI：0.6-3.2）、涂覆木材（OR=1.4，95%CI：0.5-3.9）或林业工作（OR=1.7，95%CI：0.5-6.4）的既往或同时暴露与风险增加也无统计学意义。暴露滞后并未改变结果。
在汽车工人队列中观察到的发病率过高，几乎不能用之前或同时从事农业或林业工作来解释。由于从事农业工作的人数较少，评估农业工作与农业暴露之间的关联的统计能力有限，因此无法就与农业相关的暴露与 GCC 风险的关联得出最终结论。
