Glacet-Bernard A, Chabanel A, Coscas G, Lelong F, Samama M
Clinique Ophtalmologique Universitaire, Université Paris XII, Créteil, France.
J Fr Ophtalmol. 1990;13(10):500-5.
Erythrocyte aggregation is one of the principal determinants of blood viscosity at low shear rates (low flow). Anatomical and hemodynamical characteristics make retinal venous circulation particularly dependent on hemorheological factors. Erythrocyte aggregation and other laboratory parameters (haematocrit, fibrinogen, plasma proteins, clotting) were measured in 85 patients presenting with retinal vein occlusion and 64 controls matched for age, sex and vascular risk factors (hypertension, diabetes, smoking). Statistical analysis of the results demonstrated a significant difference between the retinal vein occlusion group an the control group for erythrocyte aggregation (p less than 0.001 for the aggregation index at 10 sec and for the threshold of dissociation). The fibrinogen level, haematocrit and plasma proteins (albumin, IgA, IgG, IgM, total proteins, 2-macroglobulin) were similar in the two groups. No statistically significant difference for erythrocyte aggregation was observed between occlusions of the venous branch and occlusions of the central retinal vein or between ischaemic and non-ischaemic forms. These results suggest that raised erythrocyte aggregation mainly explains the increase in blood viscosity previously demonstrated, and could play a role in the constitution of retinal vein occlusion.
红细胞聚集是低剪切速率（低流量）下血液粘度的主要决定因素之一。解剖学和血液动力学特征使视网膜静脉循环特别依赖于血液流变学因素。对85例视网膜静脉阻塞患者和64例年龄、性别及血管危险因素（高血压、糖尿病、吸烟）相匹配的对照组进行了红细胞聚集及其他实验室参数（血细胞比容、纤维蛋白原、血浆蛋白、凝血）的测量。结果的统计分析表明，视网膜静脉阻塞组与对照组在红细胞聚集方面存在显著差异（10秒时的聚集指数和解离阈值p均小于0.001）。两组的纤维蛋白原水平、血细胞比容和血浆蛋白（白蛋白、IgA、IgG、IgM、总蛋白、α2-巨球蛋白）相似。在静脉分支阻塞与视网膜中央静脉阻塞之间或缺血性与非缺血性形式之间，未观察到红细胞聚集有统计学显著差异。这些结果表明，红细胞聚集增加主要解释了先前证实的血液粘度升高，并可能在视网膜静脉阻塞的形成中起作用。
