Cortinovis A, Crippa A, Crippa M
IRCCS Policlinico San Matteo di Pavia, Dipartimento di Medicina Interna e Terapia Medica, Università degli Studi di Pavia.
Minerva Med. 1994 May;85(5):211-9.
In 32 patients with retinal vein occlusion we measured coagulative and hematic parameters. The coagulative factors were in the normal range, save C-Protein, that was decreased and the Von Willebrand Factor that appeared increased in a significant way. These changes do not affect the coagulation state, but, in a local vascular district, they can interfere with mechanisms of thromboresistance, over all in the retinal district owing to its peculiar structure and its flow of terminal kind. The hemorheologic alterations consist in a decrease in the erythrocyte deformability and in an increase in the plasma-erythrocyte and plasma viscosities, measured both with a rotational method and with a filtering one. We have not found any correlation between coagulative factors and hemorheologic parameters, nevertheless these last ones determine a lowering down of the local flow, that with the morphological changes in the vascular system, give rise to conditions for an occlusion event.
在32例视网膜静脉阻塞患者中，我们测量了凝血和血液参数。凝血因子处于正常范围，但C蛋白降低，血管性血友病因子显著升高。这些变化并不影响凝血状态，但在局部血管区域，它们可能会干扰抗血栓形成机制，尤其是在视网膜区域，因为其结构特殊且血流为终末型。血液流变学改变包括红细胞变形性降低，以及用旋转法和过滤法测得的血浆-红细胞黏度和血浆黏度增加。我们未发现凝血因子与血液流变学参数之间存在任何相关性，然而，这些血液流变学参数会导致局部血流降低，再加上血管系统的形态学变化，就会引发阻塞事件的发生。
