使用激光多普勒测速仪测量原发性开角型青光眼和正常眼压性青光眼的视神经乳头血流及血液流变学
Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open angle glaucoma and normal pressure glaucoma.
作者信息
Hamard P, Hamard H, Dufaux J, Quesnot S
机构信息
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France.
出版信息
Br J Ophthalmol. 1994 Jun;78(6):449-53. doi: 10.1136/bjo.78.6.449.
Abstract
Optic disc blood flow velocity was measured in healthy patients, those with primary open angle glaucoma (POAG), and patients with normal pressure glaucoma (NPG). The velocity of the red blood cells (RBCs) in the capillaries of the optic nerve head (ONH) has been measured with a laser Doppler velocimeter (LDV), and blood viscosity has been evaluated notably by determining the aggregability of the RBCs with an erythroaggregameter. Our results in POAG patients and NPG patients showed that their optic nerve blood flow velocity was reduced and that the aggregability of the RBCs was increased. The hyperaggregability of the erythrocytes is responsible for the increase of the local viscosity in the papillary capillary network. These haemodynamic modifications observed in patients with glaucoma support the hypothesis of a vasogenic mechanism that could impair the optic nerve in glaucoma patients.
摘要
在健康患者、原发性开角型青光眼（POAG）患者和正常眼压性青光眼（NPG）患者中测量了视盘血流速度。使用激光多普勒测速仪（LDV）测量了视神经乳头（ONH）毛细血管中红细胞（RBC）的速度，并通过用红细胞聚集仪测定RBC的聚集性来显著评估血液粘度。我们在POAG患者和NPG患者中的结果表明，他们的视神经血流速度降低，RBC的聚集性增加。红细胞的高聚集性导致乳头毛细血管网络中局部粘度增加。在青光眼患者中观察到的这些血液动力学改变支持了一种血管生成机制的假说，该机制可能损害青光眼患者的视神经。
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