Experimental Paediatrics, Department of Paediatrics, Doctoral School in Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.
Bone Marrow Transplant. 2011 May;46(5):727-32. doi: 10.1038/bmt.2010.184. Epub 2010 Sep 6.
Oral mucositis (OM) is a common side effect experienced during haematopoietic SCT (HSCT), and it can have a significant impact on the quality of life of patients. A descriptive nurse-led study was undertaken in 19-member centres of the Italian national transplant group (GITMO) evaluating incidence, severity and duration of OM in patients undergoing HSCT. Data from 1841 patients between 2002 and 2006 was analyzed. Initial medical history and oral cavity assessment was performed. Assessment was repeated on the day of transplant, then daily, using the WHO (World Health Organisation) oral toxicity scale. A total of 71% of the patients evaluated developed mucositis and 21.6% developed severe mucositis. Duration of OM in most cases lasted for 10-14 days and resolved along with marrow reconstitution. Oral mucostitis is a frequent side effect in patients undergoing HSCT. The onset of severe mucositis seems to be related to the conditioning regimen used. This database provides a descriptive overview of the incidence and severity of mucositis and has encouraged participating centres to adopt routine evaluation and measurement of the oral cavity. The assessment tools are still used in some centres, providing a basis for further collaborative research projects.
口腔黏膜炎是造血干细胞移植（HSCT）过程中常见的副作用，会显著影响患者的生活质量。意大利国家移植组（GITMO）的 19 个成员中心开展了一项描述性护士主导的研究，评估了 HSCT 患者口腔黏膜炎的发生率、严重程度和持续时间。对 2002 年至 2006 年间的 1841 例患者的数据进行了分析。对初始病史和口腔进行评估。在移植当天、随后每天使用世界卫生组织（WHO）口腔毒性量表重复评估。评估的患者中有 71%出现黏膜炎，21.6%出现严重黏膜炎。大多数患者的口腔黏膜炎持续 10-14 天，随着骨髓重建而缓解。口腔黏膜炎是 HSCT 患者常见的副作用。严重黏膜炎的发生似乎与所用的预处理方案有关。该数据库提供了口腔黏膜炎发生率和严重程度的描述性概述，并鼓励参与中心采用常规的口腔评估和测量。一些中心仍在使用这些评估工具，为进一步的合作研究项目提供了基础。
