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活体肝移植中胆管的定制式可延长重建。

Tailored telescopic reconstruction of the bile duct in living donor liver transplantation.

机构信息

Center for Liver Cancer, National Cancer Center, Goyang-Si, Gyeonggi-Do, Republic of Korea.

出版信息

Liver Transpl. 2010 Sep;16(9):1069-74. doi: 10.1002/lt.22116.

Abstract

Duct-to-duct reconstruction (DDR) of the bile duct has recently become the preferred choice in living donor liver transplantation (LDLT), but biliary complications still remain the most common cause of morbidity. We introduce our new technique of tailored telescopic reconstruction (TTR) of the bile duct for reducing bile duct complications in LDLT: the hilar plate covering the right and left hepatic ducts is bisected lengthwise through the right or left hepatic duct opening to make a funnel-shaped top, into which the donor hepatic duct is telescoped to match the recipient bile duct in size, and DDR is performed in the inner tissue of good vascular integrity of the recipient bile duct without redundancy. Forty-five consecutive LDLT procedures from January to August 2008 were analyzed through a comparison of 23 conventional duct-to-duct reconstructions (cDDRs) and 22 TTRs in bile duct anastomoses. At a mean follow-up of 19.5 months, the rates of overall biliary complications, leakage, and strictures were 43.5%, 26.1%, and 34.8%, respectively, for cDDR and 9.1%, 0%, and 9.1%, respectively, for TTR (P < 0.05 for each). In conclusion, TTR of the bile duct results in excellent outcomes with respect to minimization of biliary complications; thus, TTR can be recommended as a preferred method for biliary reconstruction in LDLT.

摘要

胆管对端吻合(DDR)最近已成为活体肝移植(LDLT)的首选方法,但胆管并发症仍然是发病率最高的原因。我们介绍一种新的胆管定制伸缩重建(TTR)技术,用于减少 LDLT 中的胆管并发症:将覆盖左右肝管的肝门板通过右或左肝管开口纵向切开,形成漏斗形顶部,将供体肝管套入其中,使其与受体胆管大小匹配,在受体胆管具有良好血管完整性的内层组织中进行 DDR,没有冗余。通过比较 2008 年 1 月至 8 月的 45 例连续 LDLT 手术,分析了 23 例传统胆管对端吻合术(cDDR)和 22 例 TTR 胆管吻合术。在平均随访 19.5 个月时,cDDR 的总胆管并发症、漏液和狭窄发生率分别为 43.5%、26.1%和 34.8%,TTR 分别为 9.1%、0%和 9.1%(P<0.05)。总之,TTR 可显著减少胆管并发症,从而获得良好的胆管重建效果,因此可推荐 TTR 作为 LDLT 胆管重建的首选方法。

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