Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark.
Environ Health. 2010 May 10;9:22. doi: 10.1186/1476-069X-9-22.
In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure.
We related LC/MS/MS measurements of CB-153 and p,p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland.
In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p,p'-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153>200 ng/g lipid compared to 0-25 ng CB-153/g lipid and OR of 2.5 CI (0.9-6.6) for p,p'-DDE>1500 ng/g lipid compared to 0-250 ng DDE/g lipid. However, no clear dose response associations were observed. The results further suggest that high level of organochlorine serum concentrations may be related to repeated loss.
The risk of fetal loss may increase at higher levels of CB-153 and p,p'-DDE exposure, although lack of dose response and inconsistencies between countries did not allow for firm conclusions.
在本研究中，目的是研究与环境 2,2',4,4',5,5'-六氯联苯（CB-153）或 1,1-二氯-2,2-双（对氯苯基）乙烯（p,p'-DDE）暴露相关的胎儿丢失风险。
我们将 LC/MS/MS 测量的血清样本中的 CB-153 和 p,p'-DDE 与波兰、乌克兰和格陵兰孕妇人群的先前胎儿丢失访谈数据相关联。
共对 1710 名妇女进行了访谈，其中 678 名妇女至少有一次先前妊娠。随着 CB-153 和 p,p'-DDE 暴露水平的升高，经历过胎儿丢失的风险增加，与 CB-153>200ng/g 脂质相比，0-25ng CB-153/g 脂质的调整后比值比（OR）为 2.4；置信区间（CI）（1.1-5.5），与 p,p'-DDE>1500ng/g 脂质相比，0-250ng DDE/g 脂质的 OR 为 2.5 CI（0.9-6.6）。然而，没有观察到明确的剂量反应关联。结果进一步表明，高水平的有机氯血清浓度可能与反复丢失有关。
胎儿丢失的风险可能会随着 CB-153 和 p,p'-DDE 暴露水平的升高而增加，尽管缺乏剂量反应和国家之间的不一致性，无法得出明确的结论。
