Shen L-H, Zhang X-M, Su D-J, Yao S-P, Yu B-Q, Wang H-W, Lu F-Z
Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
J Int Med Res. 2010 May-Jun;38(3):1093-8. doi: 10.1177/147323001003800337.
Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation and it is thought that neutrophils play a major role in the disease pathogenesis. Genetic polymorphism of the vitamin-D-binding protein (VDBP) gene is considered one of the candidates for variation in susceptibility to COPD. To evaluate the potential influences of VDBP gene polymorphisms on COPD, a case-control study was conducted in the Han population of north-east China. The VDBP polymorphic site was genotyped in 100 COPD patients and 100 controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. A significantly higher proportion of VDBP-1F homozygosity was found in COPD patients, while the frequency of VDBP-2 homozygosity was significantly lower in COPD patients, which seemed to suggest that VDBP-2 homozygocity provided a protective effect. These data suggest that the VDBP gene may be involved in COPD susceptibility in Chinese Han population.
慢性阻塞性肺疾病（COPD）的特征是慢性气流受限，并且人们认为中性粒细胞在该疾病的发病机制中起主要作用。维生素D结合蛋白（VDBP）基因的遗传多态性被认为是COPD易感性变异的候选因素之一。为了评估VDBP基因多态性对COPD的潜在影响，在中国东北汉族人群中进行了一项病例对照研究。对100例COPD患者和100例对照者的VDBP多态性位点进行基因分型。通过聚合酶链反应-限制性片段长度多态性确定基因型。在COPD患者中发现VDBP-1F纯合子的比例显著更高，而COPD患者中VDBP-2纯合子的频率显著更低，这似乎表明VDBP-2纯合性具有保护作用。这些数据表明，VDBP基因可能与中国汉族人群的COPD易感性有关。
