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[印度尼西亚生药的药理活性成分研究。III. 鸦胆子(鸦胆子)的有毒成分]

[Studies on pharmacologically active principles from Indonesian crude drugs. III. Toxic components from Brucea javanica (L.) Merr].

作者信息

Okuyama E, Gao L H, Yamazaki M

机构信息

Faculty of Pharmaceutical Sciences, Chiba University, Japan.

出版信息

Yakugaku Zasshi. 1990 Nov;110(11):834-8. doi: 10.1248/yakushi1947.110.11_834.

Abstract

During our screening of pharmacologically active principles from Indonesian medicinal plants by a hypothermic effect the methanol-extract of Brucea javanica (L.) Merr. has been found to exhibit a lethal toxicity to mice. The toxic components were isolated and identified with bruceoside A and B and yadanzioside F. Correction of 13C-nuclear magnetic resonance assignment was also mentioned.

摘要

在我们通过低温效应筛选印尼药用植物的药理活性成分的过程中,发现鸦胆子(Brucea javanica (L.) Merr.)的甲醇提取物对小鼠具有致命毒性。分离并鉴定出毒性成分是鸦胆子苷A和B以及鸦胆子素F。文中还提到了对13C核磁共振归属的校正。

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