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[印度尼西亚生药的药理活性成分研究。III. 鸦胆子（鸦胆子）的有毒成分]

[Studies on pharmacologically active principles from Indonesian crude drugs. III. Toxic components from Brucea javanica (L.) Merr].

作者信息

Okuyama E, Gao L H, Yamazaki M

机构信息

Faculty of Pharmaceutical Sciences, Chiba University, Japan.

出版信息

Yakugaku Zasshi. 1990 Nov;110(11):834-8. doi: 10.1248/yakushi1947.110.11_834.

DOI:10.1248/yakushi1947.110.11_834
PMID:2082013
Abstract

During our screening of pharmacologically active principles from Indonesian medicinal plants by a hypothermic effect the methanol-extract of Brucea javanica (L.) Merr. has been found to exhibit a lethal toxicity to mice. The toxic components were isolated and identified with bruceoside A and B and yadanzioside F. Correction of 13C-nuclear magnetic resonance assignment was also mentioned.

摘要

在我们通过低温效应筛选印尼药用植物的药理活性成分的过程中，发现鸦胆子（Brucea javanica (L.) Merr.）的甲醇提取物对小鼠具有致命毒性。分离并鉴定出毒性成分是鸦胆子苷A和B以及鸦胆子素F。文中还提到了对13C核磁共振归属的校正。

相似文献

1
[Studies on pharmacologically active principles from Indonesian crude drugs. III. Toxic components from Brucea javanica (L.) Merr].[印度尼西亚生药的药理活性成分研究。III. 鸦胆子（鸦胆子）的有毒成分]
Yakugaku Zasshi. 1990 Nov;110(11):834-8. doi: 10.1248/yakushi1947.110.11_834.
2
Yadanzioside P, a new antileukemic quassinoid glycoside from Brucea javanica (L.) Merr with the 3-O-(beta-D-glucopyranosyl)bruceantin structure.鸦胆子苷P，一种来自鸦胆子（Brucea javanica (L.) Merr）的具有3 - O -（β - D - 吡喃葡萄糖基）鸦胆子丁结构的新型抗白血病苦木素苷。
Chem Pharm Bull (Tokyo). 1986 Oct;34(10):4447-50. doi: 10.1248/cpb.34.4447.
3
Antitumor agents, 65. Brusatol and cleomiscosin-A, antileukemic principles from Brucea javanica.抗肿瘤剂，65. 鸦胆子醇和臭矢菜素A，来自鸦胆子的抗白血病成分。
J Nat Prod. 1984 May-Jun;47(3):550-1. doi: 10.1021/np50033a030.
4
Studies on the constituents of Indonesian Picrasma javanica. III. Structures of new quassinoids, javanicins A, C and D.印度尼西亚爪哇苦木的成分研究。III. 新苦木素类化合物爪哇苦木素A、C和D的结构
Chem Pharm Bull (Tokyo). 1989 Nov;37(11):2991-4. doi: 10.1248/cpb.37.2991.
5
Antitumor agents, 127. Bruceoside C, a new cytotoxic quassinoid glucoside, and related compounds from Brucea javanica.
J Nat Prod. 1992 Apr;55(4):468-75. doi: 10.1021/np50082a011.
6
Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica.鸦胆子苷D、E和F，从鸦胆子中分离得到的三种新的具有细胞毒性的苦木素类糖苷。
J Nat Prod. 1995 Jul;58(7):1032-8. doi: 10.1021/np50121a007.
7
[Studies on the chemical constituents of Brucea javanica (L.) Merr].
Yao Xue Xue Bao. 1990;25(5):382-6.
8
Antitumor agents, 93. Bruceanol C, a new cytotoxic quassinoid from Brucea antidysenterica.抗肿瘤剂，93. 鸦胆子醇C，一种来自鸦胆子的新型细胞毒性苦木素。
J Nat Prod. 1988 Mar-Apr;51(2):349-52. doi: 10.1021/np50056a031.
9
Antitumor agents, 104. Isolation of yadanziosides M and P from Brucea antidysenterica and identification of bruceantinoside B as a mixture of yadanzioside P and bruceantinoside C.抗肿瘤剂，104. 从鸦胆子中分离雅胆子苷M和P并鉴定鸦胆子新苷B为雅胆子苷P和鸦胆子新苷C的混合物
J Nat Prod. 1989 Mar-Apr;52(2):398-401. doi: 10.1021/np50062a033.
10
[Studies on the chemical components of Brucea javanica].[鸦胆子化学成分的研究]
Zhong Yao Cai. 1998 Aug;21(8):398-400.

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