鸦胆子苷D、E和F，从鸦胆子中分离得到的三种新的具有细胞毒性的苦木素类糖苷。

Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica.

作者信息

Ohnishi S, Fukamiya N, Okano M, Tagahara K, Lee K H

机构信息

Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima, Japan.

出版信息

J Nat Prod. 1995 Jul;58(7):1032-8. doi: 10.1021/np50121a007.

DOI:10.1021/np50121a007

PMID:7561896

Abstract

Three new quassinoid glucosides, bruceosides D [1], E [2], and F [3], were isolated from Brucea javanica, and their structures were elucidated by spectral evidence and chemical transformation to known compounds. Compounds 1-3 show selective cytotoxicity in the leukemia and non-small cell lung, colon, CNS, melanoma, and ovarian cancer cell lines with log GI50 values in the range of -4.14 to -5.72.

摘要

从鸦胆子中分离出三种新的苦木素类糖苷，鸦胆子苷D [1]、E [2]和F [3]，并通过光谱证据和化学转化为已知化合物来阐明它们的结构。化合物1-3在白血病、非小细胞肺癌、结肠癌、中枢神经系统、黑色素瘤和卵巢癌细胞系中显示出选择性细胞毒性，其对数GI50值在-4.14至-5.72范围内。