Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Int J Obes (Lond). 2011 May;35(5):744-7. doi: 10.1038/ijo.2010.188. Epub 2010 Sep 7.
There is emerging evidence that persistent organic pollutants (POPs) can increase the risk of various chronic diseases. As POPs mainly bioaccumulate in adipose tissue, weight change can affect serum concentrations of POPs. However, there are few population-based studies on effects of long-term weight change on serum concentrations of POPs. We examined associations between self-reported weight change over 1 year and 10 years and serum concentrations of seven POPs in 1099 adults aged ≥ 40. Serum concentrations of most POPs were higher in those with long-term weight loss, whereas they were lower in those with long-term weight gain. Adjusted correlation coefficients of each POP with weight change for 10 years were -0.23 (P < 0.01) for trans-nonachlor, -0.16 (P < 0.01) for p,p'-dichlorodiphenyldichloroethylene, and -0.21 (P < 0.01) for β-hexachlorocyclohexane, -0.16 (P < 0.01) for PCB169, -0.20 (P < 0.01) for PCB180 and -0.17 (P < 0.01) for 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. Weight change for 1 year showed similar but weaker associations, compared with those of long-term weight changes. Although both beneficial health effects after weight loss and harmful health effects after weight gain are generally expected, changes in serum concentrations of POPs in relation to weight change may act on health in directions opposite to what we expect with weight change.
越来越多的证据表明，持久性有机污染物（POPs）会增加各种慢性疾病的风险。由于 POPs 主要在脂肪组织中生物积累，体重变化会影响 POPs 的血清浓度。然而，关于长期体重变化对 POPs 血清浓度影响的人群研究较少。我们研究了 1099 名年龄≥40 岁的成年人在 1 年和 10 年内自我报告的体重变化与七种 POPs 的血清浓度之间的关系。在长期体重减轻的人群中，大多数 POPs 的血清浓度较高，而在长期体重增加的人群中，它们的血清浓度较低。调整后的每种 POP 与 10 年体重变化的相关系数分别为反式-非氯（trans-nonachlor）-0.23（P<0.01）、p,p'-二氯二苯二氯乙烯（p,p'-dichlorodiphenyldichloroethylene）-0.16（P<0.01）、β-六氯环己烷（β-hexachlorocyclohexane）-0.21（P<0.01）、PCB169-0.16（P<0.01）、PCB180-0.20（P<0.01）和 1,2,3,4,6,7,8-七氯二苯并对二恶英（1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin）-0.17（P<0.01）。与长期体重变化相比，一年的体重变化显示出类似但较弱的关联。虽然一般来说，体重减轻后的有益健康效应和体重增加后的有害健康效应都可以预期，但 POPs 血清浓度与体重变化的关系变化可能会对健康产生与我们预期的体重变化相反的影响。
