Centre for Public Health Research, Massey University, 6021 Wellington, New Zealand.
AsureQuality Ltd., 5010 Lower Hutt, New Zealand.
Sci Total Environ. 2018 Feb 15;615:624-631. doi: 10.1016/j.scitotenv.2017.09.331. Epub 2017 Oct 6.
A national survey was conducted in 2011-2013 to assess serum concentrations of persistent organic pollutants (POPs) in adult New Zealanders. Participants were randomly selected from the 2010 Electoral Roll within 64 demographic strata according to 4 age groups, 4 regions, 2 ethnic groups (Māori/non-Māori) and gender. Eligible subjects (n=734) donated up to 30ml of blood, after which serum was pooled (n=49) according to demographic strata prior to analysis by GC-HRMS. Associations between demographic variables (age, region, ethnicity, gender) and serum POPs were assessed using linear regression. The weighted geometric mean (GM) of PCDD/Fs was 5.3pg/g lipid toxic equivalents using the WHO 2005 toxic equivalence factors (TEQ), which increased by age (3.2, 4.4, 4.8, and 8.1pg/g lipid for the 19-24, 25-34, 35-49, and 50-64year age groups, respectively). The weighted GM of dioxin-like PCBs was 1.4pg TEQ/g lipid which also increased by age (0.82, 0.86, 1.4, and 2.3pg/g lipid for the same age groups, respectively). Of the detected OCPs, the highest concentration was observed for p,p'-DDE (weighted GM, 220ng/g lipid) followed by hexachlorobenzene (HCB; 7.3ng/g lipid), beta-HCH (7.0ng/g lipid), and dieldrin (4.7ng/g lipid). For most Cl-POPs, concentrations were lowest in the youngest age group, and were similar for men and women and Māori and non-Māori. Serum Cl-POPs were, on average, 50% lower than those measured 15years earlier in 1997. This survey provides evidence of declining serum concentrations of chlorinated POPs in the New Zealand adult population. Age was the most important determinant of POPs concentrations. Body burdens of PCDD/Fs and PCBs in New Zealand are relatively low by international comparison, while for OCPs they are similar or lower compared to those reported for other developed countries.
2011-2013 年进行了一项全国性调查，以评估成年新西兰人体内持久性有机污染物（POPs）的血清浓度。根据年龄组、4 个地区、2 个人群（毛利人/非毛利人）和性别，从 2010 年选举名单中随机选择参与者进入 64 个人口统计学分层。符合条件的研究对象（n=734）最多捐献 30ml 血液，之后根据人口统计学分层将血清混合（n=49），然后采用气相色谱-高分辨质谱法进行分析。使用线性回归分析评估人口统计学变量（年龄、地区、种族、性别）与血清 POPs 之间的关系。采用世界卫生组织 2005 年毒性等效因子（TEQ）计算，二恶英样多氯联苯的加权几何均值（GM）为 PCDD/Fs 5.3pg/g 脂质毒性当量，且随年龄增加而升高（19-24 岁、25-34 岁、35-49 岁和 50-64 岁年龄组分别为 3.2、4.4、4.8 和 8.1pg/g 脂质）。二恶英样多氯联苯的加权 GM 为 1.4pg TEQ/g 脂质，也随年龄增加而升高（19-24 岁、25-34 岁、35-49 岁和 50-64 岁年龄组分别为 0.82、0.86、1.4 和 2.3pg/g 脂质）。在所检测的 OCPs 中，p,p'-DDE 的浓度最高（加权 GM，220ng/g 脂质），其次是六氯苯（HCB；7.3ng/g 脂质）、β-六氯环己烷（β-HCH；7.0ng/g 脂质）和狄氏剂（4.7ng/g 脂质）。对于大多数氯代 POPs，浓度在最年轻的年龄组中最低，且男性与女性、毛利人与非毛利人之间相似。与 15 年前（1997 年）相比，血清氯代 POPs 的平均浓度降低了 50%。本研究提供了新西兰成年人群体中氯化 POPs 浓度下降的证据。年龄是 POPs 浓度的最重要决定因素。与国际比较，新西兰的 PCDD/Fs 和多氯联苯的体内负荷相对较低，而与其他发达国家报告的 OCPs 相比，它们相似或更低。
