用光响应金纳米粒子开关从热敏性金纳米粒子-脂质体中释放药物。
Photoinduced drug release from thermosensitive AuNPs-liposome using a AuNPs-switch.
机构信息
School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China.
出版信息
Chem Commun (Camb). 2010 Oct 14;46(38):7202-4. doi: 10.1039/c0cc03142a. Epub 2010 Aug 27.
PMID:20820547
Abstract
A thermosensitive liposome with embedded AuNPs in a bilayer was prepared using supercritical CO(2). The AuNPs-liposome can absorb a certain wavelength light, convert optical energy into heat, induce phase transition, and release drug. The results show that drug release from the liposome is due to the photothermic effects inducing phase transition of the liposome rather than destruction of the liposome structure.
摘要
采用超临界 CO(2) 制备了一种双层嵌入 AuNPs 的热敏脂质体。AuNPs-脂质体可以吸收一定波长的光，将光能量转化为热能，诱导相变，并释放药物。结果表明，脂质体的药物释放是由于光热效应诱导脂质体相变，而不是破坏脂质体结构。
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