Bi Hongshu, Xue Jianxiu, Jiang Hong, Gao Shan, Yang Dongjuan, Fang Yan, Shi Kai
Institute of New Drug Development, Liaoning Yaolian Pharmaceutical Co., Ltd., Benxi, Liaoning 117004, China.
School of Pharmacy, Shenyang Pharmaceutical University, Benxi, Liaoning 117004, China.
Asian J Pharm Sci. 2019 Jul;14(4):365-379. doi: 10.1016/j.ajps.2018.07.006. Epub 2018 Oct 31.
Thermosensitive liposomes (TSLs) have been an important research area in the field of tumor targeted chemotherapy. Since the first TSLs appeared that using 1,2-dipalmitoyl-sn-glyce-ro-3-phosphocholine (DPPC) as the primary liposomal lipid, many studies have been done using this type of liposome from basic and practical aspects. While TSLs composed of DPPC enhance the cargo release near the phase transition temperature, it has been shown that many factors affect their temperature sensitivity. Thus numerous attempts have been undertaken to develop new TSLs for improving their thermal response performance. The main objective of this review is to introduce the development and recent update of innovative TSLs formulations, including combination of radiofrequency ablation (RFA), high-intensity focused ultrasound (HIFU), magnetic resonance imaging (MRI) and alternating magnetic field (AMF). In addition, various factors affecting the design of TSLs, such as lipid composition, surfactant, size and serum components are also discussed.
热敏脂质体（TSLs）一直是肿瘤靶向化疗领域的一个重要研究方向。自从首个以1,2 - 二棕榈酰 - sn - 甘油 - 3 - 磷酸胆碱（DPPC）作为主要脂质体脂质的热敏脂质体出现以来，已经从基础和实际应用方面对这类脂质体开展了许多研究。虽然由DPPC组成的热敏脂质体在相变温度附近能促进药物释放，但研究表明许多因素会影响其温度敏感性。因此，人们进行了大量尝试来开发新型热敏脂质体以改善其热响应性能。本综述的主要目的是介绍创新型热敏脂质体制剂的发展及最新进展，包括射频消融（RFA）、高强度聚焦超声（HIFU）、磁共振成像（MRI）和交变磁场（AMF）的联合应用。此外，还讨论了影响热敏脂质体设计的各种因素，如脂质组成、表面活性剂、大小和血清成分等。
