Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Lipids Health Dis. 2010 Sep 7;9:96. doi: 10.1186/1476-511X-9-96.
Low level of high density lipoprotein cholesterol (HDL-C) has high prevalence in the Tehran Lipid and Glucose Study (TLGS) cohort. About 50% of the inter-individual variation in serum HDL-C levels is genetically determined. Polymorphisms in cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) genes have been found to be associated with the metabolism and serum concentration of the HDL-C.
To determine the association between Taq1B polymorphism in CETP gene and -514C/T polymorphism in LIPC gene with serum lipid levels and lipid peroxidation in a subgroup of the TLGS population.
Serum HDL-C level had significant association with CETP Taq1B polymorphism and B2B2 subjects had the highest HDL-C levels compared to B2B1 and B1B1 genotypes (37.9 vs. 36.9 and 35.3 mg/dl, respectively; P = 0.01). However, carriers of "B1" allele, in comparison to the non carriers (B2B2), had significantly lower levels of TC (200.1 vs. 215.2 mg/dl; P = 0.005), HDL-C (35.8 vs. 37.9 mg/dl; P = 0.009) and malondialdehyde MDA (4.5 vs. 5.0 nmol/mL; P=0.031). Carriers of the "T" allele in -514C/T polymorphism in LIPC gene had higher means of HDL-C than non carriers (37.7 vs. 35.7 mg/dl, P = 0.04). No other association was found between -514C/T polymorphism and any other serum lipids or MDA level.
This study demonstrates the association between Taq1B and -514C/T polymorphisms in the CETP and LIPC genes with the serum HDL-C levels.
高密度脂蛋白胆固醇（HDL-C）水平低在德黑兰血脂和血糖研究（TLGS）队列中很常见。大约 50%的血清 HDL-C 水平的个体间差异是由遗传决定的。胆固醇酯转移蛋白（CETP）和肝脂肪酶（LIPC）基因的多态性与 HDL-C 的代谢和血清浓度有关。
在 TLGS 人群的亚组中，确定 CETP 基因 Taq1B 多态性与 LIPC 基因-514C/T 多态性与血清脂质水平和脂质过氧化的关系。
血清 HDL-C 水平与 CETP Taq1B 多态性显著相关，B2B2 受试者的 HDL-C 水平最高，与 B2B1 和 B1B1 基因型相比（分别为 37.9、36.9 和 35.3mg/dl；P=0.01）。然而，与非携带者（B2B2）相比，携带“B1”等位基因的个体 TC（200.1 与 215.2mg/dl；P=0.005）、HDL-C（35.8 与 37.9mg/dl；P=0.009）和丙二醛 MDA（4.5 与 5.0nmol/mL；P=0.031）水平显著较低。LIPC 基因-514C/T 多态性中“T”等位基因的携带者比非携带者的 HDL-C 均值更高（37.7 与 35.7mg/dl，P=0.04）。在-514C/T 多态性与其他任何血清脂质或 MDA 水平之间未发现其他关联。
本研究表明 CETP 和 LIPC 基因的 Taq1B 和-514C/T 多态性与血清 HDL-C 水平有关。
