Department of Molecular and Cell Biology, University of California, Berkeley, USA.
Curr Opin Pharmacol. 2010 Dec;10(6):670-5. doi: 10.1016/j.coph.2010.08.006. Epub 2010 Sep 6.
SnoN (Ski-novel protein) was discovered as a nuclear proto-oncogene on the basis of its ability to induce transformation of chicken and quail embryonic fibroblasts. As a crucial negative regulator of transforming growth factor-β (TGF-β) signaling and also an activator of p53, it plays an important role in regulating cell proliferation, senescence, apoptosis, and differentiation. Recent studies of its expression patterns and functions in mouse models and mammalian cells have revealed important functions of SnoN in normal epithelial development and tumorigenesis. Evidence suggests that SnoN has both pro-oncogenic and anti-oncogenic functions by modulating multiple signaling pathways. These studies suggest that SnoN may have broad functions in the development and homeostasis of embryonic and postnatal tissues.
SnoN（Ski-新颖蛋白）是作为核原癌基因被发现的，基于其诱导鸡和鹌鹑胚胎成纤维细胞转化的能力。作为转化生长因子-β（TGF-β）信号的关键负调节剂，也是 p53 的激活剂，它在调节细胞增殖、衰老、凋亡和分化方面发挥着重要作用。最近在小鼠模型和哺乳动物细胞中对其表达模式和功能的研究揭示了 SnoN 在正常上皮发育和肿瘤发生中的重要功能。有证据表明，SnoN 通过调节多种信号通路具有致癌和抑癌双重功能。这些研究表明，SnoN 在胚胎和出生后组织的发育和动态平衡中可能具有广泛的功能。
