Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Diabetes Care. 2010 Dec;33(12):2623-5. doi: 10.2337/dc10-0912. Epub 2010 Sep 7.
The association between low birth weight and type 2 diabetes is well established. We studied whether preterm birth carries a similar risk.
The Helsinki Birth Cohort includes 13,345 men and women born between 1934 and 1944. Of them, 12,813 had adequate data on length of gestation, which we linked with data on special reimbursement for diabetes medication.
Of the subjects, 5.1% had received special reimbursement after age 40. In subjects born before 35 weeks of gestation, the odds ratio for diabetes was 1.68 (95% CI 1.06-2.65) compared with that in those born at term. After adjustment for birth weight relative to length of gestation, the odds ratio was 1.59 (1.00-2.52).
Preterm birth before 35 weeks of gestation is associated with an increased risk of type 2 diabetes in adult life. The risk is independent of that associated with slow fetal growth.
低出生体重与 2 型糖尿病之间存在密切关联。本研究旨在探讨早产是否也存在类似风险。
赫尔辛基出生队列包括 1934 年至 1944 年间出生的 13345 名男性和女性。其中，有 12813 人关于妊娠期的资料完整，我们将其与糖尿病药物特殊报销数据相联系。
在研究对象中，有 5.1%的人在 40 岁后获得了特殊报销。与足月出生的人相比，在妊娠 35 周前出生的人患糖尿病的比值比为 1.68（95%CI 1.06-2.65）。校正出生体重与妊娠期的关系后，比值比为 1.59（1.00-2.52）。
妊娠 35 周前的早产与成年后患 2 型糖尿病的风险增加相关。这种风险独立于与胎儿生长缓慢相关的风险。
