NF-κB：学无止境。
NF-kappaB: much learned, much to learn.
机构信息
Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 609 Charles E. Young Drive East, Los Angeles, CA 90095, USA.
出版信息
Sci Signal. 2010 Sep 7;3(138):pe29. doi: 10.1126/scisignal.3138pe29.
Although NF-kappaB (nuclear factor kappaB) was discovered less than 25 years ago, it is one of the most well-studied transcription factors. It plays critical roles in various immune and cellular processes, and its dysregulation is a major driver of cancer and inflammatory pathology. A new book published by Cold Spring Harbor Laboratory Press, NF-kappaB: A Network Hub Controlling Immunity, Inflammation, and Cancer, provides a series of excellent reviews on the architecture, regulation, and pathophysiological roles of NF-kappaB signaling by some of the leading investigators in the field.
尽管核因子 kappaB（NF-κB）是在不到 25 年前被发现的，但它是研究最为透彻的转录因子之一。它在各种免疫和细胞过程中发挥着关键作用，其失调是癌症和炎症病理的主要驱动因素。冷泉港实验室出版社出版的一本新书《NF-κB：控制免疫、炎症和癌症的网络枢纽》，由该领域的一些顶尖研究人员对 NF-κB 信号的结构、调控和病理生理学作用进行了一系列精彩的综述。
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