Irvin R W, Szot P, Dorsa D M, Potegal M, Ferris C F
Department of Physiology, University of Massachusetts Medical Center, Worcester 01655.
Physiol Behav. 1990 Nov;48(5):693-9. doi: 10.1016/0031-9384(90)90213-n.
Microinjection of arginine vasopressin into the lateral septum and bed nucleus of the stria terminalis of male hamsters stimulates intense flank marking and flank gland grooming, while microinjections of vasopressin in sites immediately adjacent to these areas or in the lateral ventricle are ineffective. Microinjections of oxytocin, angiotensin II and the behaviorally active C-terminal fragment of vasopressin, metabolite neuropeptide, by comparison, do not stimulate flank marking. Effective sites for vasopressin injection are clearly superimposable upon autoradiographically defined sites of high V1-receptor density. Furthermore, vasopressin-sensitive neurons in the lateral septum and bed nucleus of the stria terminalis are necessary for the expression of naturally elicited flank marking since the microinjection of a V1-receptor antagonist into these sites was able to temporarily block flank marking triggered by odors from conspecifics.
向雄性仓鼠的外侧隔区和终纹床核微量注射精氨酸加压素会刺激强烈的胁腹标记和胁腹腺梳理行为，而在紧邻这些区域的部位或侧脑室微量注射加压素则无效。相比之下，微量注射催产素、血管紧张素II以及具有行为活性的加压素C末端片段（代谢物神经肽）不会刺激胁腹标记。加压素注射的有效部位显然与放射自显影确定的高V1受体密度部位重叠。此外，外侧隔区和终纹床核中对加压素敏感的神经元对于自然引发的胁腹标记表达是必需的，因为向这些部位微量注射V1受体拮抗剂能够暂时阻断由同种个体气味触发的胁腹标记。
