Ramm P, Smith C T
Department of Psychology, Brock University, St. Catharines, Ontario, Canada.
Physiol Behav. 1990 Nov;48(5):749-53. doi: 10.1016/0031-9384(90)90220-x.
Using L-[1-14C]leucine autoradiography, rates of cerebral and local cerebral protein synthesis were studied during wakefulness, slow wave sleep (SWS) and REM sleep in the rat. In the cerebrum as a whole, the rate at which labelled leucine was incorporated into tissues was positively correlated with the occurrence of slow wave sleep. We failed to observe a significant correlation of protein synthesis rate with either wakefulness or REM sleep. As in the cerebrum as a whole, most discrete brain regions showed moderate positive correlations between the occurrence of SWS and rates of protein synthesis. There were no brain regions in which rates of protein synthesis showed striking correlations with sleep-wake states. Thus, the occurrence of SWS is associated with higher rates of protein synthesis throughout the brain. These data suggest that SWS sleep favors the restoration of cerebral proteins.
利用L-[1-¹⁴C]亮氨酸放射自显影技术，研究了大鼠在清醒、慢波睡眠（SWS）和快速眼动睡眠期间大脑整体及局部脑区的蛋白质合成速率。在整个大脑中，标记亮氨酸掺入组织的速率与慢波睡眠的出现呈正相关。我们未观察到蛋白质合成速率与清醒或快速眼动睡眠之间存在显著相关性。与整个大脑情况一样，大多数离散脑区的慢波睡眠出现与蛋白质合成速率之间呈中度正相关。没有脑区的蛋白质合成速率与睡眠-觉醒状态呈现显著相关性。因此，慢波睡眠的出现与全脑较高的蛋白质合成速率相关。这些数据表明，慢波睡眠有利于脑蛋白的恢复。
