Yan Benedict, Seng Sim Chee, Petersson Fredrik
Department of Pathology, National University Hospital Systems, Singapore.
Appl Immunohistochem Mol Morphol. 2011 Jan;19(1):76-81. doi: 10.1097/PAI.0b013e3181ec8a50.
The clinicopathologic features of the first case of a thymoma with a strong nuclear expression of thyroid transcription factor-1 are reported. The thymoma was classified as type AB according to the WHO-system. No definitive correlation between the different histologic patterns or neoplastic cell types and thyroid transcription factor-1 expression was discerned. No immunohistochemical evidence of neuroendocrine differentiation was identified with synaptophysin, chromogranin A, and CD56.
报告了首例甲状腺转录因子-1核表达强的胸腺瘤的临床病理特征。根据世界卫生组织系统，该胸腺瘤被分类为AB型。未发现不同组织学模式或肿瘤细胞类型与甲状腺转录因子-1表达之间存在明确关联。使用突触素、嗜铬粒蛋白A和CD56未发现神经内分泌分化的免疫组化证据。
