人类快速眼动睡眠期间的皮质反应性和有效连接性。
Cortical reactivity and effective connectivity during REM sleep in humans.
作者信息
Massimini M, Ferrarelli F, Murphy Mj, Huber R, Riedner Ba, Casarotto S, Tononi G
机构信息
Department of Clinical Sciences, University of Milan, via G.B. Grassi 74, Milan 20157, Italy.
出版信息
Cogn Neurosci. 2010 Sep;1(3):176-183. doi: 10.1080/17588921003731578.
Abstract
We recorded the electroencephalographic (EEG) responses evoked by transcranial magnetic stimulation (TMS) during the first rapid eye movement (REM) sleep episode of the night and we compared them with the responses obtained during previous wakefulness and NREM sleep. Confirming previous findings, upon falling into NREM sleep, cortical activations became more local and stereotypical, indicating a significant impairment of the intracortical dialogue. During REM sleep, a state in which subjects regain consciousness but are almost paralyzed, TMS triggered more widespread and differentiated patterns of cortical activation, that were similar to the ones observed in wakefulness. Similarly, TMS/hd-EEG may be used to probe the internal dialogue of the thalamocortical system in brain injured patients that are unable to move and communicate.
摘要
我们记录了夜间首次快速眼动（REM）睡眠阶段经颅磁刺激（TMS）诱发的脑电图（EEG）反应，并将其与之前清醒和非快速眼动（NREM）睡眠期间获得的反应进行比较。正如之前的研究结果所证实的，进入NREM睡眠时，皮层激活变得更加局部化和刻板化，这表明皮层内对话存在显著受损。在REM睡眠期间，即受试者恢复意识但几乎瘫痪的状态下，TMS引发了更广泛且有差异的皮层激活模式，这与清醒时观察到的模式相似。同样，TMS/高密度脑电图（hd-EEG）可用于探究无法移动和交流的脑损伤患者丘脑皮质系统的内部对话。
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