Pierscionek Barbara K
School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, UK.
Cell Tissue Bank. 2011 Feb;12(1):23-4. doi: 10.1007/s10561-010-9207-3. Epub 2010 Sep 8.
For research on human physiology and pathologies the most relevant results come from human tissue, necessitating the creation of more tissue banks. This need is acknowledged by academics, clinical researchers and the pharmaceutical industry. For academics, the major obstacles to establishing tissue banks are the somewhat cumbersome ethical procedures, a perceived lack of demand for human tissue and insufficient knowledge about supply and its demographic differences. The causes are inter-related: confusing and time-consuming ethics applications cause some researchers to avoid human tissue work and expend research efforts on animal studies, leading to a false presumption of a lower level of demand for human tissue. Lack of knowledge about why rates of donation are low, and why there are differences in donation for different organs, leads to an uncertainty about supply. This too poses a problem for tissue bank establishment, and further research into this area is required.
对于人体生理学和病理学研究而言，最具相关性的结果来自人体组织，因此需要创建更多的组织库。这一需求得到了学术界、临床研究人员和制药行业的认可。对学术界来说，建立组织库的主要障碍是伦理程序有些繁琐、认为对人体组织的需求不足以及对供应情况及其人口统计学差异的了解不够。这些原因相互关联：混乱且耗时的伦理申请导致一些研究人员回避人体组织研究，而将研究精力投入到动物研究中，从而导致对人体组织需求水平较低的错误假设。对捐赠率低的原因以及不同器官捐赠存在差异的原因缺乏了解，导致供应情况存在不确定性。这也给组织库的建立带来了问题，因此需要对这一领域进行进一步研究。
