Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Int J Cancer. 2011 Jul 1;129(1):173-9. doi: 10.1002/ijc.25652. Epub 2010 Nov 9.
Scanty data are available on the incidence (i.e., the absolute risk) of second cancers of the head and neck (HN) and its pattern with age. We investigated this issue using data from a multicentric study of 13 population-based cancer registries from Europe, Canada, Australia and Singapore for the years 1943-2000. A total of 99,257 patients had a first primary HN cancer (15,985 tongue, 22,378 mouth, 20,758 pharyngeal, and 40,190 laryngeal cancer), contributing to 489,855 person-years of follow-up. A total of 1,294 of the patients (1.3%) were diagnosed with second HN cancers (342 tongue, 345 mouth, 418 pharynx and 189 larynx). Male incidence rates of first HN cancer steeply increased from 0.68/100,000 at age 30-34 to 46.2/100,000 at age 70-74, and leveled off at older age; female incidence increased from 0.50/100,000 at age 30-34 to 16.5/100,000 at age 80-84. However, age-specific incidence of second HN cancers after a first HN cancer in men was around 200-300/100,000 between age 40-44 and age 70-74 and tended to decline at subsequent ages (150/100,000 at age 80-84); in women, incidence of second HN cancers was around 200-300/100,000 between age 45-49 and 80-84. The patterns of age-specific incidence were consistent for different subsites of second HN cancer and sexes; moreover, they were similar for age-specific incidence of first primary HN cancer in patients who subsequently developed a second HN cancer. The incidence of second HN cancers does not increase with age, but remains constant, or if anything, decreases with advancing age.
有关头颈部（HN）第二癌症的发病率（即绝对风险）及其随年龄变化的模式，相关数据非常有限。我们使用欧洲、加拿大、澳大利亚和新加坡的 13 个基于人群的癌症登记处的多中心研究数据，对这一问题进行了研究。这些数据来自于 1943 年至 2000 年期间的 99257 名头颈部癌症患者（15985 例舌癌、22378 例口腔癌、20758 例咽癌和 40190 例喉癌），随访时间共计 489855 人年。共有 1294 名患者（1.3%）被诊断患有第二头颈部癌症（342 例舌癌、345 例口腔癌、418 例咽癌和 189 例喉癌）。男性头颈部癌症的发病率从 30-34 岁时的 0.68/100000 急剧上升至 70-74 岁时的 46.2/100000，之后在老年时趋于平稳；女性发病率从 30-34 岁时的 0.50/100000 上升至 80-84 岁时的 16.5/100000。然而，男性在首次头颈部癌症后的特定年龄第二头颈部癌症的发病率约为 40-44 岁至 70-74 岁之间的 200-300/100000，且在随后的年龄阶段呈下降趋势（80-84 岁时为 150/100000）；女性第二头颈部癌症的发病率约为 45-49 岁和 80-84 岁之间的 200-300/100000。第二头颈部癌症的特定年龄发病率模式在不同部位和性别之间是一致的；此外，它们与随后发生第二头颈部癌症的患者的特定年龄第一原发头颈部癌症的发病率相似。第二头颈部癌症的发病率不会随年龄增长而增加，而是保持不变，或者随着年龄的增长而下降。
