Division of Cardiovascular Diseases, VA North Texas Healthcare System and University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Catheter Cardiovasc Interv. 2011 Apr 1;77(5):657-61. doi: 10.1002/ccd.22763. Epub 2011 Mar 8.
To evaluate the intercatheter reproducibility of catheter-based intracoronary near-infrared spectroscopy (NIRS) for the detection of coronary lipid core plaques (LCPs).
The intercatheter in vivo reproducibility of coronary NIRS findings has not been evaluated.
NIRS assessment using an automated pullback catheter was performed in triplicates in 10 patients using two different NIRS catheters to evaluate the reproducibility of the lipid core burden index (LCBI).
Mean age was 62 ± 7 years, and all patients were men with high prevalence of hypertension (90%), hyperlipidemia (90%), diabetes (50%), and current smoking (50%). The mean LCBI measured by the first and second catheters was 64 ± 55 and 69 ± 47, respectively (intraclass correlation coefficient, 0.97; 95% confidence interval, 0.90-0.99; and Spearman's ρ, 0.95; P < 0.001 for both). The mean LCBI measured again with the second catheter was 71 ± 63 (intraclass correlation coefficient, 0.96; 95% confidence interval, 0.84-0.99; and Spearman's ρ, 0.95; P < 0.001 for both). The mean number of LCPs detected by the first and second catheters was 1.9 ± 1.2 and 2.0 ± 1.5, respectively (intraclass correlation coefficient, 0.75, P = 0.005 and Spearman's ρ, 0.74, P = 0.01). The mean number of LCPs at reimaging with the second catheter was 2.0 ± 1.76 (intraclass correlation coefficient, 0.96 and Spearman's ρ, 0.98; P < 0.001 for both).
NIRS measurements of LCP with two different catheters have high reproducibility. The findings support the use of NIRS to assess the status of LCP in patients over time and to assess LCP changes in response to novel treatments.
评估基于导管的冠状动脉近红外光谱（NIRS）检测冠状动脉脂质核心斑块（LCP）的导管内可重复性。
尚未评估冠状动脉 NIRS 检测结果的导管内体内可重复性。
使用自动回撤导管对 10 例患者进行 NIRS 评估，使用两种不同的 NIRS 导管进行三次重复，以评估脂质核心负担指数（LCBI）的可重复性。
平均年龄为 62±7 岁，所有患者均为男性，高血压患病率为 90%，高脂血症为 90%，糖尿病为 50%，当前吸烟率为 50%。第一根和第二根导管测量的平均 LCBI 分别为 64±55 和 69±47（组内相关系数为 0.97；95%置信区间为 0.90-0.99；Spearman's ρ 为 0.95；两者均 P<0.001）。第二次使用第二根导管再次测量的平均 LCBI 为 71±63（组内相关系数为 0.96；95%置信区间为 0.84-0.99；Spearman's ρ 为 0.95；两者均 P<0.001）。第一根和第二根导管检测到的平均 LCP 数量分别为 1.9±1.2 和 2.0±1.5（组内相关系数为 0.75，P=0.005，Spearman's ρ 为 0.74，P=0.01）。第二次使用第二根导管进行重成像的平均 LCP 数量为 2.0±1.76（组内相关系数为 0.96，Spearman's ρ 为 0.98；两者均 P<0.001）。
两种不同导管的 LCP 的 NIRS 测量具有很高的可重复性。这些发现支持使用 NIRS 随时间评估患者 LCP 的状态，并评估新型治疗方法对 LCP 的影响。
