Veteran Affairs North Texas Healthcare System, Dallas, TX, USA.
Catheter Cardiovasc Interv. 2010 Sep 1;76(3):359-65. doi: 10.1002/ccd.22500.
To evaluate the reproducibility of catheter-based intracoronary near-infrared spectroscopy (NIRS) for the detection of lipid core coronary plaques (LCPs) and to examine stenting-induced changes in NIRS findings.
The in-vivo reproducibility of coronary NIRS findings and their changes after stenting have not previously been characterized.
NIRS assessment using an automated pullback catheter was performed in duplicate in 36 vessels in 31 patients. The reproducibility of the Lipid Core Burden Index (LCBI) and the presence and number of LCPs was assessed. The changes in LCBI after stenting were also assessed in 25 vessels in 22 patients.
LCBI of the first and second pullback was 64 ± 43 and 70 ± 62, respectively, with excellent correlation (Spearman's rho 0.927, intraclass correlation coefficient 0.925). Depending on LCP definition, mean LCP length, and median LCP number ranged from 2.44 to 17.25 mm, and from 0 to 2, respectively per artery studied. High correlation was observed between the two pullbacks for total LCP length (depending on the LCP definition used, the Spearman's rho and the intraclass correlation coefficient ranged from 0.72 to 0.89, and from 0.76 to 0.91, respectively) and for LCP number (depending on the LCP definition used, the Spearman's rho and the intraclass correlation coefficient ranged from 0.70 to 0.87, and from 0.67 to 0.88, respectively). The mean LCBI decreased by 40% from 78 ± 47 to 48 ± 38 after stenting (P < 0.001).
The LCBI and LCP length NIRS measurements have high reproducibility. LCBI significantly decreases after coronary stenting.
评估基于导管的冠状动脉近红外光谱（NIRS）检测脂质核心斑块（LCPs）的可重复性，并研究支架置入后 NIRS 检测结果的变化。
冠状动脉 NIRS 检测结果的体内可重复性及其支架置入后的变化尚未得到充分描述。
对 31 例患者的 36 个血管进行了两次自动回撤导管 NIRS 评估。评估了脂质核心负担指数（LCBI）及其存在和 LCP 数量的可重复性。还在 22 例患者的 25 个血管中评估了支架置入后 LCBI 的变化。
第一次和第二次回撤的 LCBI 分别为 64 ± 43 和 70 ± 62，相关性极好（Spearman's rho 0.927，组内相关系数 0.925）。根据 LCP 定义，平均 LCP 长度和中位数 LCP 数量分别为 2.44 至 17.25mm 和 0 至 2 个/研究血管。两次回撤的总 LCP 长度（取决于使用的 LCP 定义，Spearman's rho 和组内相关系数范围为 0.72 至 0.89，0.76 至 0.91）和 LCP 数量（取决于使用的 LCP 定义，Spearman's rho 和组内相关系数范围为 0.70 至 0.87，0.67 至 0.88）之间存在高度相关性。支架置入后 LCBI 平均降低 40%，从 78 ± 47 降至 48 ± 38（P < 0.001）。
LCBI 和 LCP 长度 NIRS 测量具有高度可重复性。冠状动脉支架置入后 LCBI 显著降低。
