Zahn P K, Sabatowski R, Schug S A, Stamer U M, Pogatzki-Zahn E M
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Münster, Albert-Schweitzer-Str. 33, 48129 Münster.
Anaesthesist. 2010 Oct;59(10):940-52. doi: 10.1007/s00101-010-1773-z.
Since paracetamol was first synthesized in 1878 it has become one of the most popular and widely used drugs for the first-line treatment of fever and pain. The reasons for this popularity are a wide variety of formulations, an assumed positive safety record and the wide availability as an over-the-counter drug. However, recently several studies questioned the positive risk-benefit ratio of paracetamol for postoperative pain by observing several possible adverse effects and limitations. The aim of the present review is to give an update of the recent literature on the efficacy of paracetamol for postoperative pain and on the value of the clinical relevance of different adverse effects of paracetamol. Finally, based on the current findings the authors try to assess the role of paracetamol for the treatment of postoperative pain.
自1878年对乙酰氨基酚首次合成以来，它已成为用于发热和疼痛一线治疗的最受欢迎且使用最广泛的药物之一。其受欢迎的原因包括多种剂型、假定良好的安全记录以及作为非处方药广泛可得。然而，最近的几项研究通过观察到一些可能的不良反应和局限性，对乙酰氨基酚用于术后疼痛的正性风险效益比提出了质疑。本综述的目的是更新关于乙酰氨基酚治疗术后疼痛疗效以及乙酰氨基酚不同不良反应临床相关性价值的近期文献。最后，基于当前研究结果，作者试图评估乙酰氨基酚在术后疼痛治疗中的作用。
