Department of Botany, University of Fort Hare, Alice, South Africa.
J Med Food. 2010 Oct;13(5):1210-5. doi: 10.1089/jmf.2009.0211.
The liver and kidney functional indices of weanling albino rats (Rattus norvegicus) maintained on different accessions (offspring of a variety planted/collected at a specific location and time but differing in certain morphological characteristics) of cooked Colocasia esculenta (cocoyam)-based diets (UFCe1-UFCe7) for 28 days were investigated. All the accessions of C. esculenta-based diets did not significantly (P > .05) alter the serum levels of albumin, globulin, inorganic phosphorus, calcium, magnesium, and uric acid of the animals.The total protein and total bilirubin levels decreased only in the UFCe3- and UFCe4-fed animals, respectively. Whereas UFCe1 and UFCe2 significantly decreased the conjugated bilirubin levels, UFCe3 and UFCe6 increased it. While all the accessions of C. esculenta-based diet decreased the serum alkaline phosphatase activity, γ-glutamyl transferase activity was increased. UFCe1 and UFCe5 increased the serum alanine aminotransferase activity, whereas UFCe4 decreased the activity of the enzyme. Again, UFCe3 and UFCe1 increased the serum creatinine and aspartate aminotransferase activity of the animals. Furthermore, the computed blood urea nitrogen:creatinine ratio was higher in animals maintained on UFCe1-, UFCe3-, UFCe4-, and UFCe5-based diets. Whereas UFCe6 and UFCe7 increased the level of sodium in the serum of the animals, UFCe4 and UFCe5 decreased the chloride level. The serum urea level was decreased by UFCe1, UFCe3, UFCe4, and UFCe5, whereas the potassium level increased in the UFCe4-, UFCe6-, and UFCe7-fed animals. Overall, the results revealed that all the accessions of C. esculenta produced selective effects on the hepatic and renal functional indices of the weanling rats. The highest alterations were produced by UFCe4, whereas the least was from UFCe2. These alterations may have consequential effects on the normal functioning of the liver and kidney of the animals. UFCe2 exhibited the least toxicity risk among the accessions of C. esculenta growing in the KwaZulu-Natal Province of South Africa.
研究了白化幼鼠（Rattus norvegicus）在不同栽培品种（在特定地点和时间种植/收集的后代，但在某些形态特征上有所不同）的烹饪大蕉（Colocasia esculenta，芋艿）饮食（UFCe1-UFCe7）中维持 28 天后的肝肾功能指标。所有的芋艿饮食都没有显著改变动物血清白蛋白、球蛋白、无机磷、钙、镁和尿酸水平（P >.05）。只有在 UFCe3 和 UFCe4 喂养的动物中，总蛋白和总胆红素水平降低。而 UFCe1 和 UFCe2 显著降低了结合胆红素水平，UFCe3 和 UFCe6 则增加了它。虽然所有的芋艿饮食都降低了血清碱性磷酸酶活性，但 γ-谷氨酰转移酶活性增加。UFCe1 和 UFCe5 增加了血清丙氨酸氨基转移酶活性，而 UFCe4 降低了该酶的活性。再次，UFCe3 和 UFCe1 增加了动物的血清肌酐和天冬氨酸氨基转移酶活性。此外，在以 UFCe1、UFCe3、UFCe4 和 UFCe5 为基础的饮食中，计算出的血尿素氮与肌酐比值更高。而 UFCe6 和 UFCe7 增加了动物血清中的钠水平，UFCe4 和 UFCe5 则降低了氯水平。UFCe1、UFCe3、UFCe4 和 UFCe5 降低了血清尿素水平，而 UFCe4、UFCe6 和 UFCe7 喂养的动物中钾水平升高。总的来说，结果表明，芋艿的所有栽培品种都对幼鼠的肝肾功能指标产生了选择性影响。UFCe4 产生的影响最大，而 UFCe2 产生的影响最小。这些变化可能对动物的肝脏和肾脏的正常功能产生影响。在南非夸祖鲁-纳塔尔省生长的芋艿栽培品种中，UFCe2 表现出的毒性风险最小。
