Department of Otolaryngology, Hillman Cancer Centre, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.
Int Immunopharmacol. 2011 Mar;11(3):331-41. doi: 10.1016/j.intimp.2010.08.014. Epub 2010 Sep 8.
Inflammation is a disease of vigorous uncontrolled activated immune responses. Overwhelming reports have suggested that the modulation of immune responses by curcumin plays a dominant role in the treatment of inflammation and metabolic diseases. Observations from both in-vitro and in-vivo studies have provided strong evidence towards the therapeutic potential of curcumin. These studies have also identified a plethora of biological targets and intricate mechanisms of action that characterize curcumin as a potent 'drug' for numerous ailments. During inflammation the functional influence of lymphocytes and the related cross-talk can be modulated by curcumin to achieve the desired immune status against diseases. This review describes the regulation of immune responses by curcumin and effectiveness of curcumin in treatment of diseases of diverse nature.
炎症是一种由过度活跃的免疫反应引起的疾病。大量报告表明，姜黄素对免疫反应的调节在炎症和代谢性疾病的治疗中起着主导作用。体外和体内研究的观察结果为姜黄素的治疗潜力提供了有力的证据。这些研究还确定了大量的生物靶点和复杂的作用机制，使姜黄素成为治疗多种疾病的有效“药物”。在炎症过程中，姜黄素可以调节淋巴细胞的功能影响和相关的串扰，以达到针对疾病的理想免疫状态。本综述描述了姜黄素对免疫反应的调节作用及其在治疗多种疾病中的有效性。
