Aggarwal Bharat B, Sung Bokyung
Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Trends Pharmacol Sci. 2009 Feb;30(2):85-94. doi: 10.1016/j.tips.2008.11.002. Epub 2008 Dec 26.
Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases. Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor kappaB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6). Because of the crucial role of inflammation in most chronic diseases, the potential of curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of curcumin have been examined in animals and in humans. Various pharmacological aspects of curcumin in vitro and in vivo are discussed in detail here.
姜黄素（二阿魏酰甲烷）是香料姜黄（也称为咖喱粉）中的一种黄色色素，几个世纪以来一直被用于治疗炎症性疾病。过去二十年的广泛研究表明，姜黄素通过下调炎症转录因子（如核因子κB）、酶（如环氧合酶2和5-脂氧合酶）和细胞因子（如肿瘤坏死因子、白细胞介素1和白细胞介素6）来介导其抗炎作用。由于炎症在大多数慢性疾病中起着关键作用，因此已经在肿瘤、神经、心血管、肺部和代谢疾病中研究了姜黄素的潜力。已经在动物和人类中研究了姜黄素的药效学和药代动力学。本文详细讨论了姜黄素在体外和体内的各种药理学方面。
