Burlakova E B, Pal'mina N P, Sezina I P
Vopr Med Khim. 1978 May-Jun;24(3):368-71.
Alterations of lipid antioxidative activity in liver and tumor as well as change in weight of spleen and tumor were studied in mice with hepatoma-22 after administration of synthetic antioxidant 4-methyl-2,6-ditertbutylphenol (ionol) at doses 30 mg/kg and 100 mg/kg during the 6th day of growth of the tumor. Lipid antioxidative activity was shown to respond similarly to administration of ionol in liver tissue of both the intact and tumor-bearing animals. The antioxidative activity was increased after administration of these doses of the antioxidant, then the antioxidative activity was decreased down to the initial level when the dose 30 mg/kg was used and below this level--at the dose 100 mg/kg. Both doses of the drug increased the lipid antioxidative activity in tumor. The dose 30 mg/kg of ionol stimulated the growth of the tumor and increased the weight of spleen in tumor-bearing animals and the dose 100 mg/kg--inhibited these parameters. Regulation of oxidation of the lipids in tumor appears to be impaired or altered to another level as compared with the oxidation of lipids in normal tissues or in the tissues of tumor-bearing animals.
在肝癌-22小鼠肿瘤生长的第6天，以30mg/kg和100mg/kg的剂量给予合成抗氧化剂4-甲基-2,6-二叔丁基苯酚（生育酚）后，研究了肝脏和肿瘤中脂质抗氧化活性的变化以及脾脏和肿瘤重量的变化。结果表明，完整动物和荷瘤动物肝脏组织中，脂质抗氧化活性对生育酚的给药反应相似。给予这些剂量的抗氧化剂后，抗氧化活性增加，然后当使用30mg/kg剂量时，抗氧化活性降至初始水平，而当使用100mg/kg剂量时，抗氧化活性降至该水平以下。两种剂量的药物均增加了肿瘤中的脂质抗氧化活性。30mg/kg剂量的生育酚刺激了荷瘤动物肿瘤的生长并增加了脾脏重量，而100mg/kg剂量则抑制了这些参数。与正常组织或荷瘤动物组织中的脂质氧化相比，肿瘤中脂质氧化的调节似乎受损或改变到了另一个水平。
