Romanenko E B, Alesenko A V, Burlakova E B
Vopr Med Khim. 1986 May-Jun;32(3):122-6.
Relationship between alterations in the state of lipid antioxidative activity (AOA) and the patterns of blood coagulation system (content of fibrinogen, the rate of fibrinolytic activity and the period of blood coagulation) were studied after administration of a synthetic antioxidant ionol into animals and after partial hepatectomy and with Ehrlich ascites hepatoma. An increase in the lipid AOA in animal tissues correlated with a decrease in fibrinolytic activity and in the blood coagulation period. Concentration of fibrinogen was decreased similarly after hepatectomy and after the antioxidant administration. In the course of development of Ehrlich ascites hepatoma concentration of fibrinogen was increased. Interrelationship found between the alterations in lipid AOA and the patterns of blood coagulation as well as distinct impairment of these relations during malignant growth confirmed high importance of alterations in the rate of oxidative reactions for the processes of blood coagulation.
在给动物注射合成抗氧化剂离子醇后、部分肝切除术后以及艾氏腹水肝癌模型中，研究了脂质抗氧化活性（AOA）状态的改变与血液凝固系统模式（纤维蛋白原含量、纤溶活性速率和血液凝固时间）之间的关系。动物组织中脂质AOA的增加与纤溶活性和血液凝固时间的减少相关。肝切除术后和抗氧化剂给药后，纤维蛋白原浓度同样降低。在艾氏腹水肝癌发展过程中，纤维蛋白原浓度升高。脂质AOA改变与血液凝固模式之间的相互关系以及恶性生长过程中这些关系的明显受损，证实了氧化反应速率改变对血液凝固过程具有高度重要性。
