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衰老过程中及给予具有老年学保护作用的抗氧化剂后小鼠体内脂质的抗氧化活性。

Antioxidative activity of lipids in mice during aging and administration of an antioxidant with gerontological protective action.

作者信息

Pal'mina N P, Obukhova L K, Bunto T V, Smirnov L D

出版信息

Biol Bull Acad Sci USSR. 1979 Mar-Apr;6(2):243-6.

PMID:549672
Abstract

Changes in the antioxidative activity (AOA) of the liver were studied during natural aging in noninbred and C3HA mice and during administration of the synthetic anti-oxidant 2-ethyl-6-methyl-3-hydroxypyridine hydroxypyridine hydrochloride to the animals, and the effect of the doses of this compound on the level of AOA in the liver of animals aged 2 months also was investigated. Liver AOA in mice was found to decrease during aging; the decreae in animals with tumors was found to be two or three times slower than in animals without tumors. Administration of the compound after the age of 8 months led to a considerable increase in liver AOA, and this may evidently account for the considerable lengthening of the life of the experimental animals.

摘要

研究了非近交系和C3HA小鼠自然衰老过程中肝脏抗氧化活性（AOA）的变化，以及给动物施用合成抗氧化剂2-乙基-6-甲基-3-羟基吡啶盐酸盐期间肝脏抗氧化活性的变化，还研究了该化合物剂量对2月龄动物肝脏AOA水平的影响。发现小鼠肝脏AOA在衰老过程中降低；有肿瘤的动物中AOA的降低比无肿瘤的动物慢两到三倍。8月龄后施用该化合物导致肝脏AOA显著增加，这显然可能是实验动物寿命显著延长的原因。

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1
Antioxidative activity of lipids in mice during aging and administration of an antioxidant with gerontological protective action.衰老过程中及给予具有老年学保护作用的抗氧化剂后小鼠体内脂质的抗氧化活性。
Biol Bull Acad Sci USSR. 1979 Mar-Apr;6(2):243-6.
2
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