Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
J Clin Neurosci. 2010 Dec;17(12):1553-6. doi: 10.1016/j.jocn.2010.04.034. Epub 2010 Sep 9.
Hepatocyte growth factor (HGF), also known as scatter factor, promotes the survival and migration of immature neurons. The HGF receptor c-Met is expressed in neurons. HGF plays an important role as a neurotrophic factor in the brain. HGF is produced by a wide variety of cells and is found in many physiological fluids, including serum and cerebrospinal fluid (CSF). Since CSF is in contact with the extracellular space of the brain, biochemical brain modifications are, to some extent, reflected in the CSF, and peptide and growth factors in the CSF can be used as biomarkers of disease. In this study, CSF and serum HGF concentrations were measured in patients with Parkinson's disease. The study population comprised 33 patients with Parkinson's disease and 38 normal controls. Western blot analysis using an anti-HGF antibody confirmed the presence of HGF in serum and CSF. No significant changes in serum HGF were observed in this study. However, CSF HGF expression was higher in patients with Parkinson's disease than in controls (p < 0.001). This finding indicates that HGF may be involved in the pathophysiology of Parkinson's disease.
肝细胞生长因子（HGF），也称为分散因子，可促进未成熟神经元的存活和迁移。HGF 受体 c-Met 在神经元中表达。HGF 作为一种神经营养因子在大脑中发挥重要作用。HGF 由多种细胞产生，并存在于许多生理液中，包括血清和脑脊液（CSF）。由于 CSF 与大脑的细胞外空间接触，因此脑内的生化修饰在某种程度上反映在 CSF 中，并且 CSF 中的肽和生长因子可以用作疾病的生物标志物。在这项研究中，测量了帕金森病患者的 CSF 和血清 HGF 浓度。研究人群包括 33 名帕金森病患者和 38 名正常对照者。使用抗 HGF 抗体的 Western blot 分析证实了血清和 CSF 中存在 HGF。本研究中未观察到血清 HGF 有明显变化。但是，帕金森病患者的 CSF HGF 表达高于对照组（p < 0.001）。这一发现表明 HGF 可能参与了帕金森病的病理生理学过程。
