Department of Biology, Faculty of Sciences, University of Guilan, Namjoo Street, PO Box 1914, Rasht, Iran.
J Clin Neurosci. 2010 May;17(5):623-7. doi: 10.1016/j.jocn.2009.08.013. Epub 2010 Feb 26.
Parkinson's disease (PD) is characterized by progressive loss of dopaminergic neurons in the substantia nigra. Insulin like growth factor-1 (IGF-1) promotes the survival of dopaminergic neurons and protects them from toxin-induced damage in vitro. IGF-1 is produced by a wide variety of cells and is found in many physiological fluids, including cerebrospinal fluid (CSF). IGFs in physiological fluids are associated with insulin-like growth factor binding proteins (IGFBPs), which bind to them and modulate their bioactivity at the cellular level. Since the CSF is in contact with the extracellular space of the brain, biochemical brain modifications are, to some extent, reflected in the CSF, and peptides and growth factors in the CSF can be used as biomarkers of PD. The aim of this study was to determine the concentrations of IGF-1 and IGFBPs in the serum and CSF of patients with PD. Concentrations were measured in a total of 76 CSF samples from patients with PD (n=38) and controls (n=38). Serum and CSF IGF-1 and IGFBP concentrations were higher in patients with PD than in controls (p<0.001). We conclude that IGF-1 and IGFBPs are always present in human serum and CSF, and may be involved in the pathophysiology of PD.
帕金森病（PD）的特征是黑质中多巴胺能神经元进行性丧失。胰岛素样生长因子-1（IGF-1）促进多巴胺能神经元的存活，并防止它们在体外受到毒素的损伤。IGF-1 由多种细胞产生，存在于许多生理液中，包括脑脊液（CSF）。生理液中的 IGFs 与胰岛素样生长因子结合蛋白（IGFBPs）相关联，这些蛋白与它们结合，并在细胞水平上调节它们的生物活性。由于 CSF 与大脑的细胞外空间接触，因此脑的生化改变在某种程度上反映在 CSF 中，并且 CSF 中的肽和生长因子可用作 PD 的生物标志物。本研究的目的是确定 PD 患者血清和 CSF 中 IGF-1 和 IGFBPs 的浓度。在总共 76 例 PD 患者（n=38）和对照组（n=38）的 CSF 样本中测量了浓度。PD 患者的血清和 CSF IGF-1 和 IGFBP 浓度高于对照组（p<0.001）。我们得出结论，IGF-1 和 IGFBPs 始终存在于人类血清和 CSF 中，可能参与 PD 的病理生理学。
