血细胞分化介导冈比亚按蚊的先天免疫记忆。
Hemocyte differentiation mediates innate immune memory in Anopheles gambiae mosquitoes.
机构信息
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA.
出版信息
Science. 2010 Sep 10;329(5997):1353-5. doi: 10.1126/science.1190689.
Abstract
Mosquito midgut invasion by ookinetes of the malaria parasite Plasmodium disrupts the barriers that normally prevent the gut microbiota from coming in direct contact with epithelial cells. This triggers a long-lived response characterized by increased abundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and enhanced immunity to bacteria that indirectly reduces survival of Plasmodium parasites upon reinfection. In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate immune memory.
摘要
疟原虫 Plasmodium 的子孢子在蚊子中肠的入侵破坏了通常阻止肠道微生物群与上皮细胞直接接触的屏障。这引发了一种持久的反应，其特征是粒细胞（血细胞的一个亚群）的丰度增加，并且增强了对细菌的免疫力，这间接降低了再感染时疟原虫寄生虫的存活率。在蚊子中，血细胞的分化是赋予先天免疫记忆所必需和充分的。
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