Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Ophthalmic Res. 2010;44(3):146-54. doi: 10.1159/000316594. Epub 2010 Sep 9.
Recent advances in the understanding of aging have paved a new way of thinking about intervening with the aging process. There is a global agreement in the scientific community that calorie restriction (CR) can actually extend the life span of various kinds of animals so that this has become a real intervention in aging. In addition to the CR theory, the free radical theory is another important hypothesis, which is believed to be involved in aging. According to this theory, we can manage the aging process by controlling calories or reactive oxygen species. In this paper, these two important aging theories, CR and free radical aging, are reviewed, and it is discussed how to apply these theories to the prevention and treatment of eye diseases. Finally, we share the preliminary results of our animal study on dry eye, and I report my personal experience as a dry eye patient, which has been alleviated by the antiaging approach.
近年来,人们对衰老的认识有了新的进展,为干预衰老过程开辟了新途径。科学界普遍认为,热量限制(CR)实际上可以延长各种动物的寿命,这已经成为一种真正的抗衰老干预措施。除了 CR 理论外,自由基理论是另一个重要的假说,据信它与衰老有关。根据这一理论,我们可以通过控制热量或活性氧来控制衰老过程。本文综述了这两种重要的衰老理论,即 CR 和自由基衰老,并探讨了如何将这些理论应用于眼病的防治。最后,我们分享了我们关于干眼症的动物研究的初步结果,我还报告了我作为干眼症患者的个人经历,通过抗衰老方法,我的干眼症得到了缓解。