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5-羟色胺通过 5-羟色胺 3a 受体激素调节泪腺分泌功能。

Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor.

机构信息

Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan.

Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

出版信息

Sci Rep. 2017 Jul 31;7(1):6965. doi: 10.1038/s41598-017-06022-4.

DOI:10.1038/s41598-017-06022-4
PMID:28761086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5537296/
Abstract

Tears are extracellular fluid secreted from the lacrimal gland (LG). Tears consist of a dynamic tri-layered film composed of secretions from the LG, Meibomian gland, and conjunctival goblet cells. The LG secretes the aqueous component of the tear, the Meibomian gland secretes the lipid component, and conjunctival goblet cells secrete mucin. The regulation of LG activity via the autonomic nervous system has been recognized as fundamental to maintaining aqueous tear flow. Here, we describe the role of a hormone, peripheral serotonin, in tear secretion. We found that blood serotonin concentration, changed by feeding a diet deprived of the serotonin precursor tryptophan, correlated with tear secretion, and that a sustained decrease in serotonin resulted in LG atrophy and autophagy. The combination of a decrease in serotonin with the interruption of autonomic neural stimuli to the LG preceded these alterations. Furthermore, we found that the serotonin type 3a receptor expressed in LG acinar cells is involved in tear secretion via intracellular calcium mobilization. Our findings demonstrate that hormonal regulation by serotonin, in cooperation with the autonomic nervous system, regulates tear secretion.

摘要

眼泪是由泪腺（LG）分泌的细胞外液。眼泪由 LG、睑板腺和结膜杯状细胞分泌的动态三层薄膜组成。LG 分泌泪液的水相成分，睑板腺分泌脂质成分，结膜杯状细胞分泌粘蛋白。自主神经系统对 LG 活动的调节被认为是维持水液性泪液分泌的基础。在这里，我们描述了一种激素，外周血清素，在泪液分泌中的作用。我们发现，通过喂食缺乏血清素前体色氨酸的饮食来改变血液中的血清素浓度与泪液分泌相关，而血清素的持续减少会导致 LG 萎缩和自噬。LG 自主神经刺激中断与血清素减少相结合，导致了这些变化的发生。此外，我们发现，在 LG 腺泡细胞中表达的血清素 3a 受体通过细胞内钙离子动员参与了泪液分泌。我们的研究结果表明，血清素的激素调节与自主神经系统合作，调节泪液分泌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef01/5537296/38abe4c554cb/41598_2017_6022_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef01/5537296/77bf2e37eddb/41598_2017_6022_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef01/5537296/4240f77ced40/41598_2017_6022_Fig2_HTML.jpg
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