Sastry P, Kaski J C
Division of Cardiac and Vascular Sciences, St. George's University of London, London, UK.
Drugs Today (Barc). 2010 Aug;46(8):601-8. doi: 10.1358/dot.2010.46.8.1516983.
Increasing knowledge of the atherosclerotic process, as well as atherosclerotic plaque composition and morphology, has lead to the identification of vulnerable plaques that lead to acute coronary syndromes. There is growing evidence for atherosclerotic plaque regression, which makes an aggressive targeted therapeutic response based on achieving plaques regression necessary in order to reduce the significant mortality and morbidity associated with coronary heart disease. This review will examine the evidence for atherosclerotic plaque regression, the important role of statins and the available imaging techniques used to investigate this condition. We will also discuss future evolving therapies and possible predictors of plaque regression, which may aid the therapeutic process.
对动脉粥样硬化过程以及动脉粥样硬化斑块的组成和形态的了解不断增加，已促使人们识别出导致急性冠状动脉综合征的易损斑块。越来越多的证据表明动脉粥样硬化斑块可以消退，这使得基于实现斑块消退的积极靶向治疗反应成为必要，以降低与冠心病相关的显著死亡率和发病率。本综述将探讨动脉粥样硬化斑块消退的证据、他汀类药物的重要作用以及用于研究这种情况的现有成像技术。我们还将讨论未来不断发展的治疗方法以及斑块消退的可能预测因素，这可能有助于治疗过程。
