山羊同种抗血清淋巴细胞抗原与绵羊外周血淋巴细胞及红细胞的交叉反应性。

Cross-reactivity of goat alloantisera lymphocyte antigens with ovine peripheral blood lymphocytes and erythrocytes.

作者信息

Molina A, Moreno A, Garrido J J, Morera L, Llanes D, Millot P, van Kooten P S

机构信息

Departamento de Genética, Universidad de Córdoba, Spain.

出版信息

Exp Clin Immunogenet. 1990;7(4):244-50.

PMID:2083095

Abstract

Twenty-two alloantisera that detected eleven specificities in two loci of the goat (SD1 and SD2) were studied on ovine lymphocytes from 55 Spanish Merino sheep by microlymphocytotoxicity assay. All the sera detected antigenic variability in sheep although this variability was not comparable to that described in the goat. No pancytotoxic sera were found. Agglutinating and hemolytic antibodies present in the sera were not related to any antigen present in erythrocytes and lymphocytes. Furthermore these samples were typed with sixteen ovine alloantisera and no relationship between specificities detected by ovine sera and the antigenic variability detected by goat alloreactives was found.

摘要

通过微量淋巴细胞毒性试验，对来自55只西班牙美利奴绵羊的绵羊淋巴细胞进行了研究，使用了22种检测山羊两个位点（SD1和SD2）中11种特异性的同种抗血清。所有血清都检测到了绵羊中的抗原变异性，尽管这种变异性与山羊中描述的变异性不可比。未发现全细胞毒性血清。血清中存在的凝集和溶血抗体与红细胞和淋巴细胞中存在的任何抗原均无关。此外，用16种绵羊同种抗血清对这些样本进行分型，未发现绵羊血清检测到的特异性与山羊同种反应性检测到的抗原变异性之间存在关联。