Pardal R, Ortega-Sáenz P, Durán R, Platero-Luengo A, López-Barneo J
Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/ Universidad de Sevilla, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Sevilla, Spain.
Arch Ital Biol. 2010 Jun;148(2):95-105.
We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the peripheral nervous system. These progenitor cells support neurogenesis in vivo in response to physiological stimuli like hypoxemia, and give rise to multipotent neurospheres in culture. Studying the biology of CB stem cells helps to understand the physiological adaptations of the organ, and might shed light on the pathogenesis of CB tumors. Understanding proliferation and differentiation of these cells will enable their use for cell therapy against neurodegenerative diseases.
我们已经描述了一种新的成年神经干细胞群体，它们存在于颈动脉体中，颈动脉体是外周神经系统中的一种化学感受器器官。这些祖细胞在体内对诸如低氧血症等生理刺激作出反应，支持神经发生，并在培养中产生多能神经球。研究颈动脉体干细胞的生物学特性有助于理解该器官的生理适应性，并可能为颈动脉体肿瘤的发病机制提供线索。了解这些细胞的增殖和分化将使它们能够用于针对神经退行性疾病的细胞治疗。
