核因子κB信号传导调节胚胎期和成体期神经发生。
NFκB signaling regulates embryonic and adult neurogenesis.
作者信息
Zhang Yonggang, Hu Wenhui
机构信息
Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA.
出版信息
Front Biol (Beijing). 2012 Aug;7(4). doi: 10.1007/s11515-012-1233-z.
Abstract
Both embryonic and adult neurogenesis involves the self-renewal/proliferation, survival, migration and lineage differentiation of neural stem/progenitor cells. Such dynamic process is tightly regulated by intrinsic and extrinsic factors and complex signaling pathways. Misregulated neurogenesis contributes much to a large range of neurodevelopmental defects and neurodegenerative diseases. The signaling of NFκB regulates many genes important in inflammation, immunity, cell survival and neural plasticity. During neurogenesis, NFκB signaling mediates the effect of numerous niche factors such as cytokines, chemokines, growth factors, extracellular matrix molecules, but also crosstalks with other signaling pathways such as Notch, Shh, Wnt/β-catenin. This review summarizes current progress on the NFκB signaling in all aspects of neurogenesis, focusing on the novel role of NFκB signaling in initiating early neural differentiation of neural stem cells and embryonic stem cells.
摘要
胚胎期和成年期的神经发生均涉及神经干/祖细胞的自我更新/增殖、存活、迁移和谱系分化。这一动态过程受到内在和外在因素以及复杂信号通路的严格调控。神经发生失调在很大程度上导致了一系列神经发育缺陷和神经退行性疾病。NFκB信号传导调控许多在炎症、免疫、细胞存活和神经可塑性方面重要的基因。在神经发生过程中，NFκB信号传导介导众多微环境因子如细胞因子、趋化因子、生长因子、细胞外基质分子的作用，还与其他信号通路如Notch、Shh、Wnt/β-连环蛋白发生相互作用。本综述总结了NFκB信号传导在神经发生各个方面的当前进展，重点关注NFκB信号传导在启动神经干细胞和胚胎干细胞早期神经分化中的新作用。
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