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一种绿色的一锅三组分串联反应：在水介质中合成2-氨基-5,8-二氢-3H-吡啶并[2,3-D]嘧啶-4-酮。

A green one-pot three-component cascade reaction: the synthesis of 2-amino-5,8-dihydro-3H-pyrido[2,3-D]pyrimidin-4-ones in aqueous medium.

作者信息

Shaabani Ahmad, Sepahvand Heshmatollah, Boroujeni Mahmoud Borjian, Faroghi Mohammad Tayeb

机构信息

Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.

出版信息

Mol Divers. 2017 Feb;21(1):147-153. doi: 10.1007/s11030-016-9712-9. Epub 2017 Jan 12.

DOI:10.1007/s11030-016-9712-9
PMID:28083767
Abstract

A one-pot three-component cascade reaction for the green synthesis of a new class of 2-amino-5,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-ones was developed from the condensation of aromatic aldehydes with 2,6-diaminopyrimidin-4(3H)-one and acetophenone derivatives or various cyclic ketones in the presence of a catalytic amount of sodium carbonate in a mixture of water and ethanol at 60  [Formula: see text]. This reaction led to the construction of two carbon-carbon bonds and one carbon-nitrogen bond in a single synthetic step.

摘要

开发了一种一锅三组分串联反应，用于绿色合成一类新型的2-氨基-5,8-二氢-3H-吡啶并[2,3-d]嘧啶-4-酮，该反应是在60℃下，在水和乙醇的混合物中，在催化量的碳酸钠存在下，使芳香醛与2,6-二氨基嘧啶-4(3H)-酮和苯乙酮衍生物或各种环酮缩合而成。[化学式：见正文]。该反应在一个合成步骤中构建了两个碳-碳键和一个碳-氮键。

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