Rush Alzheimer's Disease Center, Chicago, Illinois 60612, USA.
J Am Geriatr Soc. 2010 Oct;58(10):1925-30. doi: 10.1111/j.1532-5415.2010.03058.x. Epub 2010 Sep 9.
To examine the association between life space, a measure of functional status that describes the range of movement through the environment covered during daily functioning, and the risk of mortality in older community-based persons.
Two ongoing, prospective observational cohort studies of aging.
Greater metropolitan Chicago area.
One thousand four hundred forty-five community-based older persons without dementia.
Life space was measured at baseline using a series of questions designed to measure the extent of participants' movement throughout their environment, ranging from the bedroom to out of town. The association between life space and mortality was examined using proportional hazards models adjusted for age, sex, race, and education.
Over up to 8 years of follow-up (mean 4.1 years), 329 of 1,445 (22.8%) participants died. In a proportional hazards model adjusted for age, sex, race, and education, a more-constricted life space was associated with a greater risk of death (hazard ratio=1.18, 95% confidence interval=1.09-1.27, P<.001), such that people with life spaces constricted to their immediate home environment (score=3) were approximately 1.6 times as likely to die as those whose life spaces included trips out of town (score=0). This association persisted after the addition of terms for several potential confounders, including physical activity, performance-based physical function, disability, depressive symptoms, social networks, body mass index, and number of chronic medical conditions.
Constricted life space is associated with greater risk of death in older community-based persons.
探讨生活空间与死亡率之间的关系。生活空间是衡量功能状态的一个指标，描述了日常活动中穿越环境的范围。
这是两项正在进行的、前瞻性的观察性老龄化队列研究。
大芝加哥都会区。
1445 名无痴呆的社区老年人。
在基线时使用一系列问题来测量参与者在其环境中的移动范围，从卧室到城外。使用比例风险模型，根据年龄、性别、种族和教育程度调整生活空间与死亡率之间的关系。
在长达 8 年的随访期（平均 4.1 年）中，1445 名参与者中有 329 人（22.8%）死亡。在调整年龄、性别、种族和教育程度的比例风险模型中，生活空间越受限，死亡风险越高（风险比=1.18，95%置信区间=1.09-1.27，P<.001），生活空间仅限于其家庭环境的人（得分为 3）死亡的可能性大约是生活空间包括出城旅行的人的 1.6 倍（得分为 0）。在加入了几个潜在混杂因素的条件后，包括体育活动、基于表现的身体功能、残疾、抑郁症状、社交网络、体重指数和慢性疾病数量后，这种关联仍然存在。
生活空间受限与社区老年人死亡风险增加相关。
