Turov V V, Bakaĭ E A, Turov A V, Kornilov M Iu
Biofizika. 1990 Sep-Oct;35(5):770-4.
Interaction of alcohols (methanol, glycerol, sorbitol) with human serum albumin (HSA) was studied by the use of NMR spectroscopy in frozen aqueous solutions. The amount of binding was shown to increase in the series methanol-glycerol-sorbitol, on this basis a suggestion is made that interaction of alcohols with HSA occurs due to the formation of hydrogen bonds in which the hydroxyl groups act as proton donors. It is found that the presence of albumin influences significantly the outcome of eutectics from a diluted methanol solution and glycerol solution, the temperature of eutectics decreases in case of methanol and increases in case of glycerol.
通过在冷冻水溶液中使用核磁共振光谱法研究了醇类（甲醇、甘油、山梨醇）与人血清白蛋白（HSA）的相互作用。结果表明，结合量在甲醇-甘油-山梨醇系列中增加，据此提出醇类与HSA的相互作用是由于形成了氢键，其中羟基作为质子供体。研究发现，白蛋白的存在显著影响稀释甲醇溶液和甘油溶液的低共熔物结果，甲醇的低共熔温度降低，甘油的低共熔温度升高。
