Farid Karim, Volpe-Gillot Lisette, Caillat-Vigneron Nadine
AP-HP, hôpital Hôtel-Dieu, service de médecine nucléaire, 75004 Paris, France.
Presse Med. 2010 Nov;39(11):1127-31. doi: 10.1016/j.lpm.2010.06.013. Epub 2010 Sep 15.
Alzheimer Disease (AD) is the most frequent cause of degenerative dementia. There is an asymptomatic phase of the disease. Brain single photon computed tomography (SPECT) is a simple way to investigate the cerebral blood flow. Alzheimer's disease is characterized by hypoperfusion in the medial temporal, associative posterior parietal cortex and frontal cortex. Brain SPECT could also have an interest in the early detection of amnesic mild cognitive impairment (MCI) patients with a high risk of conversion to AD. Indeed, the hypoperfusion of the associative parietal cortex in MCI patients is considered predictive of a rapid conversion to AD. Different scintigraphic patterns of neurodegenerative dementias could be used for their differential diagnosis.
阿尔茨海默病（AD）是退行性痴呆最常见的病因。该病存在无症状期。脑单光子计算机断层扫描（SPECT）是一种研究脑血流的简单方法。阿尔茨海默病的特征是内侧颞叶、联合后顶叶皮质和额叶皮质灌注不足。脑SPECT对于早期检测有转化为AD高风险的遗忘型轻度认知障碍（MCI）患者也可能有帮助。事实上，MCI患者联合顶叶皮质的灌注不足被认为可预测其快速转化为AD。神经退行性痴呆的不同闪烁显像模式可用于它们的鉴别诊断。
