载脂蛋白 L55M 和 Q192R 基因多态性与突尼斯人群的心肌梗死。

The paraoxonase L55M and Q192R gene polymorphisms and myocardial infarction in a Tunisian population.

机构信息

Department of Biochemistry, Rabta University Hospital, Tunis, Tunisia.

出版信息

Clin Biochem. 2010 Dec;43(18):1461-3. doi: 10.1016/j.clinbiochem.2010.08.029. Epub 2010 Sep 15.

DOI:10.1016/j.clinbiochem.2010.08.029

PMID:20833162

Abstract

OBJECTIVES

In the present study, we examined a possible association between the PON1 Q192R and L55M polymorphisms and myocardial infarction (MI) in a sample of the Tunisian population.

DESIGN AND METHODS

Three hundred and ten patients with MI and 375 controls were recruited. Paraoxonase gene polymorphisms at codon 192 and 55 were analyzed by PCR-RFLP.

RESULTS

Genotype distributions and allele frequencies of L55M were similar among the control and MI groups. For the Q192R polymorphism patients with MI had significantly higher frequency of the RR genotype compared to controls [17.1% vs. 10.9%; OR (95% CI), 1.93 (1.24-3.02); p=0.004]. The MI patient group showed a significantly higher frequency of the R allele compared to the controls [38% vs. 30%; χ(2)=10.74, p=0.001]. The association between the PON1 Q192R polymorphism and MI remained significant after adjustment for other well-established cardiovascular risk factors.

CONCLUSIONS

The present study showed a significant and independent association between the PON1 Q192R polymorphism (presence of R allele) and MI in the Tunisian population.

摘要

目的

本研究旨在探讨在突尼斯人群样本中，PON1 Q192R 和 L55M 多态性与心肌梗死（MI）之间可能存在的关联。

设计和方法

招募了 310 名 MI 患者和 375 名对照者。通过 PCR-RFLP 分析了PON1 基因密码子 192 和 55 处的多态性。

结果

MI 患者和对照组的 L55M 基因型分布和等位基因频率相似。对于 Q192R 多态性，与对照组相比，MI 患者的 RR 基因型频率明显更高[17.1% vs. 10.9%；OR（95%CI），1.93（1.24-3.02）；p=0.004]。MI 患者组的 R 等位基因频率明显高于对照组[38% vs. 30%；χ²（2）=10.74，p=0.001]。在调整其他公认的心血管危险因素后，PON1 Q192R 多态性与 MI 之间的关联仍然显著。