在（2'-脱氧）核苷酸池中回收氧化鸟嘌呤衍生物作为 DNA 突变的来源。
Salvage of oxidized guanine derivatives in the (2'-deoxy)ribonucleotide pool as source of mutations in DNA.
机构信息
Division of Hematology and Oncology, Department of Internal Medicine, University of California Davis Medical Center, 4501 X Street, Suite 3016, Sacramento, CA 95817, USA.
出版信息
Mutat Res. 2010 Nov 28;703(1):11-7. doi: 10.1016/j.mrgentox.2010.08.021. Epub 2010 Sep 15.
Abstract
Recent evidence suggests that salvage of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanine (8-oxoGua) can contribute substantially to levels of 8-oxoGua in DNA and RNA. However, it remains to be determined if this mechanism contributes to mutagenesis and disease. This review covers the predominant methods for detecting 8-oxoGua and its derivatives, summarizes some of the relevant recent DNA repair studies and discusses the mechanisms for metabolism of oxidized guanine derivatives in the (2'-deoxy)ribonucleoside and (2'-deoxy)ribonucleotide pools.
摘要
最近的证据表明，8-氧代-7,8-二氢-2'-脱氧鸟苷（8-oxodG）和 8-氧代-7,8-二氢鸟嘌呤（8-oxoGua）的挽救可以在很大程度上导致 DNA 和 RNA 中 8-氧代鸟嘌呤（8-oxoGua）的水平。然而，尚不确定该机制是否会导致突变和疾病。本综述涵盖了检测 8-氧代鸟嘌呤及其衍生物的主要方法，总结了一些相关的最近 DNA 修复研究，并讨论了（2'-脱氧）核苷和（2'-脱氧）核苷酸池中亚氧化鸟嘌呤衍生物的代谢机制。
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