真核生物 DNA 甲基化的进化与安全性行为的追求。

Evolution of eukaryotic DNA methylation and the pursuit of safer sex.

机构信息

Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.

出版信息

Curr Biol. 2010 Sep 14;20(17):R780-5. doi: 10.1016/j.cub.2010.07.007.

DOI:10.1016/j.cub.2010.07.007

PMID:20833323

Abstract

Cytosine methylation is an ancient process with conserved enzymology but diverse biological functions that include defense against transposable elements and regulation of gene expression. Here we will discuss the evolution and biological significance of eukaryotic DNA methylation, the likely drivers of that evolution, and major remaining mysteries.

摘要

胞嘧啶甲基化是一种古老的过程，具有保守的酶学机制，但具有多样化的生物学功能，包括抵御转座元件和调控基因表达。在这里，我们将讨论真核生物 DNA 甲基化的进化和生物学意义、可能的进化驱动因素以及主要的未解之谜。